Regulation of RraA, a protein inhibitor of RNase E-mediated RNA decay.

Journal of Bacteriology
Meng ZhaoGeorge Georgiou

Abstract

The recently discovered RraA protein acts as an inhibitor of the essential endoribonuclease RNase E, and we demonstrated that ectopic expression of RraA affects the abundance of more than 700 transcripts in Escherichia coli (K. Lee, X. Zhan, J. Gao, J. Qiu, Y. Feng, R. Meganathan, S. N. Cohen, and G. Georgiou, Cell 114:623-634, 2003). We show that rraA is expressed from its own promoter, P(rraA), located in the menA-rraA intergenic region. Primer extension and lacZ fusion analysis revealed that transcription from P(rraA) is elevated upon entry into stationary phase in a sigma(s)-dependent manner. In addition, the stability of the rraA transcript is dependent on RNase E activity, suggesting the involvement of a feedback circuit in the regulation of the RraA level in E. coli.

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Citations

Jan 15, 2009·Genes & Development·Kwang-sun KimStanley N Cohen
Dec 26, 2006·Journal of Bacteriology·Timothy C BarnettJune R Scott
Jun 22, 2012·PloS One·Robert ManasherobStanley N Cohen
Sep 26, 2013·Cellular and Molecular Life Sciences : CMLS·Soumaya LaalamiHarald Putzer
May 27, 2006·Biochemical and Biophysical Research Communications·Ji-Hyun Yeom, Kangseok Lee
May 3, 2015·FEMS Microbiology Reviews·Sylvain DurandPascale Romby
Sep 30, 2017·FEBS Letters·Xuejing WangJianye Zang
Dec 18, 2012·Nature Reviews. Microbiology·George A Mackie
Nov 5, 2019·Trends in Biochemical Sciences·Alejandro Tejada-ArranzHilde de Reuse
Jul 25, 2021·Biotechnology Advances·Charlotte RouxLaurence Girbal
Nov 10, 2021·The Journal of Microbiology·Jaejin LeeKangseok Lee

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