Regulation of scar formation by vascular endothelial growth factor.

Laboratory Investigation; a Journal of Technical Methods and Pathology
Traci A WilgusLuisa A Dipietro

Abstract

Vascular endothelial growth factor (VEGF-A) is known for its effects on endothelial cells and as a positive mediator of angiogenesis. VEGF is thought to promote repair of cutaneous wounds due to its proangiogenic properties, but its ability to regulate other aspects of wound repair, such as the generation of scar tissue, has not been studied well. We examined the role of VEGF in scar tissue production using models of scarless and fibrotic repair. Scarless fetal wounds had lower levels of VEGF and were less vascular than fibrotic fetal wounds, and the scarless phenotype could be converted to a scar-forming phenotype by adding exogenous VEGF. Similarly, neutralization of VEGF reduced vascularity and decreased scar formation in adult wounds. These results show that VEGF levels have a strong influence on scar tissue formation. Our data suggest that VEGF may not simply function as a mediator of wound angiogenesis, but instead may play a more diverse role in the wound repair process.

References

Mar 23, 1979·Virchows Archiv. A, Pathological Anatomy and Histology·U Rowlatt
Dec 11, 1992·Science·A E KochR M Strieter
Oct 1, 1991·Annals of Plastic Surgery·M J MorykwasL C Argenta
Sep 1, 1991·Developmental Biology·D J Whitby, M W Ferguson
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsJ H Kehrl
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R MontesanoL Orci
Nov 1, 1989·The Journal of Clinical Investigation·D T ConnollyJ Feder
Jul 1, 1988·Journal of Pediatric Surgery·T M KrummelR F Diegelmann
Jul 1, 1987·Journal of Pediatric Surgery·T M KrummelI K Cohen
Feb 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·D M Form, R Auerbach
Nov 1, 1994·Journal of Pediatric Surgery·J H HaynesT M Krummel
Jun 1, 1997·The Surgical Clinics of North America·E E TredgetA Ghahary
Oct 27, 1997·Annals of Plastic Surgery·E J StelnickiN S Adzick
Jul 22, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A J CowinM W Ferguson
Aug 12, 1998·The Journal of Surgical Research·K W LiechtyN S Adzick
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Nov 17, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Y C JangF F Isik
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W BlochS Werner
Feb 22, 2001·The Journal of Clinical Investigation·K YanoM Detmar
Nov 17, 2001·The Journal of Investigative Dermatology·B Lange-AsschenfeldtM Detmar
Feb 5, 2002·Angiogenesis·L B NanneyC G Hellerqvist
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe CorpechotOlivier Rosmorduc
Jun 19, 2002·The Journal of Surgical Research·Christopher D RomanR Daniel Beauchamp
Feb 13, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Traci A WilgusTatiana M Oberyszyn
May 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·A Jonas EkstrandYihai Cao
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jul 5, 2003·Current Biology : CB·Paul MartinScott R McKercher
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Amy S ColwellH Peter Lorenz
Jan 23, 2004·Gene Therapy·Johannes JacobiJohn P Cooke
Feb 18, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Magali AncelinMartine Perrot-Applanat

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Citations

Jul 7, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Miguel Perez-AsoBruce N Cronstein
Nov 16, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Mateusz S WietechaLuisa A DiPietro
Jan 22, 2011·Dermatology Research and Practice·Latha Satish, Sandeep Kathju
Jun 8, 2012·ISRN Dermatology·K J Rolfe, A O Grobbelaar
Apr 24, 2014·Advances in Wound Care·Traci A Wilgus, Brian C Wulff
Oct 11, 2014·Advances in Wound Care·Kelly E Johnson, Traci A Wilgus
Oct 11, 2014·Advances in Wound Care·Luca Lancerotto, Dennis P Orgill
Jul 16, 2014·Current Eye Research·Michael J ProMarlene R Moster
Aug 15, 2014·Current Eye Research·Karolien HollandersIngeborg Stalmans
Sep 18, 2009·The Journal of Investigative Dermatology·Judith A Mack, Edward V Maytin
Nov 26, 2010·The Journal of Investigative Dermatology·Christian StockmannRandall S Johnson
Jul 23, 2014·The Journal of Investigative Dermatology·Gabrielle S Le Provost, Christine E Pullar
May 21, 2015·Journal of Plastic Surgery and Hand Surgery·Merdan Serin, Mehmet Bayramicli
May 24, 2013·Seminars in Ophthalmology·Dexter Y L Leung, Clement C Y Tham
Mar 13, 2015·Antioxidants & Redox Signaling·Mithun SinhaChandan K Sen
Jan 8, 2017·Journal of Biomedical Materials Research. Part a·Hanlei ZhouChunmao Han
Apr 8, 2017·Aesthetic Surgery Journal·Joel SchlessingerJoely Kaufman
May 28, 2016·The International Journal of Lower Extremity Wounds·Yeyang LiRixing Zhou
Oct 29, 2013·The Journal of Hand Surgery, European Volume·O A BranfordK J Rolfe
May 16, 2018·Stem Cells·Markus C DoeserGuangming Wu
Aug 25, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mohan R DasuIshwarlal Jialal
Oct 31, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Sandeep KathjuLatha Satish
Oct 31, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Yun-Shain LeeTai-Lan Tuan
Aug 25, 2010·Journal of Biomedical Materials Research. Part a·Gabriel GruionuStuart K Williams
Jul 31, 2014·Lasers in Surgery and Medicine·Karen L ConnollyDavid Ozog
Jul 25, 2018·Stem Cells and Development·Brice MagneMarina Trouillas
Aug 22, 2018·Connective Tissue Research·Jack G GrahamPedro K Beredjiklian
Aug 8, 2012·Korean Journal of Ophthalmology : KJO·Jae Ho JungHee Young Choi
Jun 13, 2015·PLoS Computational Biology·Lindsay Wendel Clegg, Feilim Mac Gabhann
Oct 29, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Brian C WulffTraci A Wilgus
Jan 5, 2011·Annals of Plastic Surgery·Mario CherubinoKacey G Marra
Nov 18, 2018·Journal of Tissue Engineering and Regenerative Medicine·Malgorzata KlocJacek Z Kubiak
Sep 2, 2009·Experimental Dermatology·Katherine LauArdeshir Bayat
Feb 17, 2010·Korean Journal of Ophthalmology : KJO·Jin Young ChoiYeon-Deok Kim
Apr 3, 2019·Tissue Engineering. Part B, Reviews·Mehri MonavarianEsmaiel Jabbari
May 3, 2014·Annals of Biomedical Engineering·Michael S HuH Peter Lorenz
Jun 21, 2012·Clinical & Experimental Ophthalmology·Rajen U DesaiShan C Lin
Nov 2, 2012·Current Opinion in Rheumatology·Luisa A DiPietro
Oct 31, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·David D LoH Peter Lorenz

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