PMID: 9542592May 30, 1998Paper

Regulation of Schwann cell numbers in tellurium-induced neuropathy: apoptosis, supernumerary cells and internodal shortening

Acta Neuropathologica
M T BercianoM Lafarga

Abstract

We have used an experimental model of tellurium(Te)-induced demyelinating neuropathy in the rat to study cellular mechanisms involved in regulating Schwann cell (SC) numbers during remyelination. Starting at postnatal day 21, weaned rats were fed a diet containing 1.1% elemental Te. Following 7 days of Te treatment and at several time points of post-tellurium treatment (PTe), the animals were processed for ultrastructural analysis, SC nuclei quantification and teased fibre preparations. It is well-established that Te induces a transient demyelinating/remyelinating sequence in sciatic nerves. The loss of the myelin sheath in this neuropathy produces active proliferation and overproduction of immature SCs. By electron microscopy analysis most mitotic SCs were located along demyelinated segments. Quantitative determination of SC nuclei per transverse section of sciatic nerve revealed a dramatic increase of SCs at 2 days PTe relative to control nerves. The number of SC nuclei then decreased progressively during the long-term period of recovery studied (330 days PTe). In Te-treated rats, SCs undergoing cell death were regularly found within the nerve fibre compartment, especially on demyelinated segments. Dying cells exhibited morph...Continue Reading

Citations

Dec 12, 2012·Molecular Neurobiology·Jun LiJiasong Guo
Apr 18, 2002·Journal of Neuroimmunology·Giancarlo ContiGuglielmo Scarlato
Dec 10, 1999·Annals of the New York Academy of Sciences·G ContiG Scarlato
Feb 11, 2005·Journal of the Peripheral Nervous System : JPNS·Teresa W C PunGreg J Stanisz
Nov 18, 2009·Muscle & Nerve·Eric LancasterSteven S Scherer
Feb 24, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Gesine SaherKlaus-Armin Nave
Dec 10, 1999·Journal of Neurobiology·C L DelaneyE L Feldman
Jun 12, 2019·Toxicologic Pathology·William M Valentine
Oct 1, 1999·Annals of the New York Academy of Sciences·G ContiG Scarlato

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis