Regulation of secondary metabolism by the carbon-nitrogen status in tobacco: nitrate inhibits large sectors of phenylpropanoid metabolism

The Plant Journal : for Cell and Molecular Biology
Christina FritzMark Stitt

Abstract

Interactions between nitrogen and carbon metabolism modulate many aspects of the metabolism, physiology and development of plants. This paper investigates the contribution of nitrate and nitrogen metabolism to the regulation of phenylpropanoid and nicotine synthesis. Wild-type tobacco was grown on 12 or 0.2 mm nitrate and compared with a nitrate reductase-deficient mutant [Nia30(145)] growing on 12 mm nitrate. Nitrate-deficient wild-type plants accumulate high levels of a range of phenylpropanoids including chlorogenic acid, contain high levels of rutin, are highly lignified, but contain less nicotine than nitrogen-replete wild-type tobacco. Nia30(145) resembles nitrate-deficient wild-type plants with respect to the levels of amino acids, but accumulates large amounts of nitrate. The levels of phenylpropanoids, rutin and lignin resemble those in nitrogen-replete wild-type plants, whereas the level of nicotine resembles that in nitrate-deficient wild-type plants. Expression arrays and real time RT-PCR revealed that a set of genes required for phenylpropanoid metabolism including PAL, 4CL and HQT are induced in nitrogen-deficient wild-type plants but not in Nia30(145). It is concluded that nitrogen deficiency leads to a marked sh...Continue Reading

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Citations

Apr 9, 2008·Journal of Chemical Ecology·Biqing SongWenxiong Lin
Apr 16, 2011·Journal of Agricultural and Food Chemistry·Jozef KovácikJosef Hedbavny
Dec 12, 2012·Journal of Experimental Botany·Kapuganti J GuptaLuis A J Mur
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Jan 29, 2013·Critical Reviews in Biochemistry and Molecular Biology·Takayuki TohgeAlisdair R Fernie
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Dec 27, 2015·Plant Science : an International Journal of Experimental Plant Biology·Jwakyung SungHari B Krishnan
Jun 29, 2012·Plant Physiology and Biochemistry : PPB·María del Mar Rubio-WilhelmiJuan Manuel Ruiz
Mar 1, 2012·Current Opinion in Plant Biology·Mechthild Tegeder
Nov 29, 2011·Plant Science : an International Journal of Experimental Plant Biology·Laura Torras-ClaveriaFrancesc Viladomat
Dec 15, 2010·Current Opinion in Biotechnology·Asaph Aharoni, Gad Galili
Jun 6, 2009·Current Opinion in Plant Biology·Anna Amtmann, Patrick Armengaud

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