Regulation of serotonin levels by multiple light-entrainable endogenous rhythms

The Journal of Experimental Biology
M WildtBarbara S Beltz

Abstract

This study examined whether serotonin levels in the brain of the American lobster, Homarus americanus, are under circadian control. Using high-performance liquid chromatography and semi-quantitative immunocytochemical methods, we measured serotonin levels in the brains of lobsters at six time points during a 24-h period. Lobsters were maintained for 2 weeks on a 12 h:12 h light:dark cycle followed by 3 days of constant darkness. Under these conditions, brain serotonin levels varied rhythmically, with a peak before subjective dusk and a trough before subjective dawn. This persistent circadian rhythm in constant darkness indicates that serotonin levels are controlled by an endogenous clock. Animals exposed to a shifted light cycle for >10 days, followed by 3 days in constant darkness, demonstrate that this rhythm is light entrainable. Separate analyses of two pairs of large deutocerebral neuropils, the accessory and olfactory lobes, show that serotonin levels in these functionally distinct areas also exhibit circadian rhythms but that these rhythms are out of phase with one another. The olfactory and accessory lobe rhythms are also endogenous and light entrainable, suggesting the presence of multiple clock mechanisms regulating s...Continue Reading

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Citations

Jan 1, 2012·Marine and Freshwater Behaviour and Physiology·Katharine R Grabek, Christopher C Chabot
Sep 14, 2011·Brain Research·Marlen Valdés-FuentesMaría Luisa Fanjul-Moles
Aug 12, 2008·General and Comparative Endocrinology·J L BentonB S Beltz
Apr 18, 2009·Developmental Neurobiology·D C SandemanB S Beltz
Nov 22, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Leonardo Rodríguez-SosaVíctor Anaya González
May 2, 2013·Behavioural Brain Research·Yusuke TominaMasakazu Takahata
Aug 24, 2006·The Journal of Comparative Neurology·Andrew M DacksJohn G Hildebrand
Jun 29, 2007·Synapse·Leonardo Rodríguez-SosaM G Porras
Feb 1, 2006·Synapse·Gabina Calderón-RoseteLeonardo Rodríguez-Sosa
Sep 5, 2009·Chronobiology International·Jeremy M SullivanDavid C Sandeman
Jan 7, 2020·The International Journal of Neuroscience·Ramanujam KarthikeyanSeithikurippu R Pandi-Perumal
Oct 19, 2010·The Journal of Experimental Biology·Elsa G Escamilla-ChimalMaría Luisa Fanjul-Moles

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