Regulation of Sertoli cell IL-1 and IL-6 production in vitro

Molecular and Cellular Endocrinology
J P StéphanB Jégou

Abstract

Interleukin-1 (IL-1) and IL-6 are pleiotropic cytokines produced by a large variety of cell types. In the testis, Sertoli cells produce IL-1alpha and IL-6. Previous studies have demonstrated that, in vitro, Sertoli cell IL-1alpha production is stimulated by some inducers of macrophage IL-1, as well as by phagocytosis of residual bodies. Furthermore, we have also shown that IL-1alpha is able to enhance Sertoli cell IL-6 production by an autocrine action. The aim of the present study was to further investigate the regulation of Sertoli cell IL-1 and IL-6 production. Three categories of potential regulators were tested; the lipopolysaccharide (LPS) and the yeast extract zymosan; follicle stimulating hormone (FSH), testosterone and dexamethasone; tumor necrosis factor alpha (TNFalpha), interferon gamma (IFNgamma) and the nerve growth factor beta (NGFbeta). It was found that zymosan (400-800 microg/ml) and LPS (20 microg/ml) stimulated Sertoli cell IL-1 and IL-6 production. FSH (1 x 10(-2)-1 microg/ml) and NGF (25-200 ug/ml) stimulated Sertoli cell IL-6 levels in a dose-dependent manner but had no effect on IL-1. The effect of testosterone on Sertoli cell IL-1 and IL-6 secretion was biphasic: dramatic increased secretion with low co...Continue Reading

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