PMID: 8603041Jan 1, 1996Paper

Regulation of sex-specific formation of oestrogen in brain development: endogenous inhibitors of aromatase

The Journal of Steroid Biochemistry and Molecular Biology
J B HutchisonR E Hutchison

Abstract

Brain sexual differentiation occurs during the steroid-sensitive phases in early development, and is affected particularly by exposure to oestrogens formed in the brain by aromatisation of androgen. The organisational effects of oestrogen result in male-specific neuronal morphology, control of reproductive behaviour, and patterns of gonadotrophin secretion. A question which still has to be resolved is what determines changes in aromatase activity effective for the differentiation of sexually dimorphic brain development during sensitive periods of growth. In the mouse, a sex difference exists at early stages of embryonic development in aromatase-containing neurones of the hypothalamus. The embryonic aromatase system is regulated later in foetal development by androgens. Testosterone treatment increases the numbers of aromatase-immunoreactive hypothalamic neuronal cell bodies. Kinetic evidence from studies on the avian brain suggest that endogenous steroid inhibitors of aromatase, probably formed within neuroglia, also have a role in the control of oestrogen production. Inhibitory kinetic constant determination of endogenous androgenic metabolites formed in the brain showed that preoptic aromatase is potently inhibited by 5 alpha...Continue Reading

References

Oct 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·A WozniakJ B Hutchison
Jan 1, 1992·Neurology·J J Halperin, M P Heyes
May 31, 1991·Brain Research·J B HutchisonR E Hutchison
May 1, 1991·The Journal of Endocrinology·M J Reed
Jun 28, 1991·Science·M OrchinikF L Moore
Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·E E Baulieu, P Robel
Mar 20, 1981·Science·N J MacLusky, F Naftolin
Jan 1, 1984·Annual Review of Neuroscience·A P Arnold, R A Gorski
Jan 1, 1984·Progress in Brain Research·J B Hutchison, T Steimer
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·M J ReedB V Potter
Jan 1, 1994·Breast Cancer Research and Treatment·P V PlourdeM Dukes
Dec 1, 1993·Neuroendocrinology·C BeyerJ B Hutchison
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·E R SimpsonC R Mendelson
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·J B Hutchison
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·J Balthazart, A Foidart
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·A Wozniak, J B Hutchison
Apr 1, 1991·Journal of Neuroendocrinology·M SchumacherJ B Hutchison

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Citations

Jun 13, 2006·Cellular and Molecular Neurobiology·Pelin Kelicen, Agneta Nordberg
Jan 2, 1997·Brain Research. Developmental Brain Research·C Beyer, J B Hutchison
Jun 19, 2001·Molecular and Cellular Endocrinology·G Séralini, S Moslemi
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·J B HutchisonR E Hutchison
May 26, 2007·Reproduction, Fertility, and Development·Chae Kwan LeeSung Goo Kang
Mar 3, 2006·Journal of Paediatrics and Child Health·Shilu TongAnthony McMichael
Jun 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Manfred Gahr
Nov 5, 1997·General and Comparative Endocrinology·N L Staub, M De Beer
Feb 9, 2000·Frontiers in Neuroendocrinology·N A Compagnone, S H Mellon

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