Regulation of sigma-1 receptors and endoplasmic reticulum chaperones in the brain of methamphetamine self-administering rats.

The Journal of Pharmacology and Experimental Therapeutics
Teruo HayashiTsung-Ping Su

Abstract

sigma-1 Receptors are endoplasmic reticulum (ER) chaperones that are implicated in the neuroplasticity associated with psychostimulant abuse. We immunocytochemically examined the distribution of sigma-1 receptors in the brain of drug-naive rats and then examined the dynamics of sigma-1 receptors and other ER chaperones in specific brain subregions of rats that self-administered methamphetamine, received methamphetamine passively, or received only saline injections. sigma-1 Receptors were found to be expressed in moderate to high levels in the olfactory bulb, striatum, nucleus accumbens shell, olfactory tubercle, amygdala, hippocampus, red nucleus, ventral tegmental area, substantia nigra, and locus ceruleus. Methamphetamine, whether self-administered or passively received, significantly elevated ER chaperones including the sigma-1 receptor, BiP, and calreticulin in the ventral tegmental area and substantia nigra. In the olfactory bulb, however, only the sigma-1 receptor chaperone was increased, and this increase occurred only in rats that actively self-administered methamphetamine. Consistent with an increase in sigma-1 receptors, extracellular signal-regulated kinase was found to be activated and protein kinase A attenuated in...Continue Reading

References

Jan 12, 1993·European Journal of Pharmacology·Y Itzhak
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M HannerH Glossmann
Jan 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·T Hayashi, T P Su
Nov 22, 2001·Journal of Computational Neuroscience·G A CecchiM O Magnasco
Mar 4, 2003·Journal of Neurophysiology·Nestor G DavilaPaul Q Trombley
May 6, 2003·The Journal of Pharmacology and Experimental Therapeutics·Teruo Hayashi, Tsung-Ping Su
Feb 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Subramaniam JayanthiJean Lud Cadet
Jun 1, 2005·Neuroscience and Biobehavioral Reviews·Cai Song, Brian E Leonard
Jun 15, 2005·Annual Review of Biochemistry·Martin Schröder, Randal J Kaufman
Feb 3, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rémi Martin-FardonFriedbert Weiss
Aug 30, 2008·The Journal of Pharmacology and Experimental Therapeutics·Yelenis HerreraJavier Cuevas
Aug 30, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rae R MatsumotoAndrew Coop
Jan 16, 2009·Trends in Cell Biology·Teruo HayashiTsung-Ping Su
Mar 13, 2009·American Journal of Physiology. Cell Physiology·Molly JohannessenMeyer B Jackson

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Citations

Nov 29, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Takato HiranitaJonathan L Katz
Aug 3, 2013·The Journal of Pharmacology and Experimental Therapeutics·Takato HiranitaJonathan L Katz
Mar 8, 2011·Expert Opinion on Therapeutic Targets·Teruo HayashiTsung-Ping Su
Jun 4, 2015·Expert Opinion on Drug Discovery·Mellar P Davis
Apr 18, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·M OhadiH Darvish
Jun 10, 2015·Journal of Receptor and Signal Transduction Research·Colin G Rousseaux, Stephanie F Greene
Aug 31, 2012·The International Journal of Neuropsychopharmacology·Michael J SeminerioRae R Matsumoto
Jun 18, 2016·Molecular Neurobiology·Bok Soon GoEun Sang Choe
Jul 31, 2013·Pharmacology, Biochemistry, and Behavior·Andrew S SageDennis K Miller
Sep 10, 2011·Pharmaceuticals·Jonathan L KatzShang-Yi Tsai
Aug 26, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Markos-Orestis GeorgiadisIoannis Papanastasiou
Dec 22, 2017·Nature Communications·Danielle O SamboHabibeh Khoshbouei
May 23, 2014·The Journal of Biological Chemistry·Katarzyna A GromekBrian G Fox
Mar 7, 2013·CNS Neuroscience & Therapeutics·Khanh V Q Luong, Lan T H Nguyễn
Jul 16, 2020·Biomolecules & Therapeutics·Buyun KimByoungduck Park
Sep 1, 2012·Addiction Biology·Tomohisa MoriTsutomu Suzuki
Jul 10, 2019·Frontiers in Cellular Neuroscience·Yanan LiChengbiao Lu
Dec 10, 2015·Current Protocols in Pharmacology·Uyen B Chu, Arnold E Ruoho
Sep 30, 2017·Frontiers in Pharmacology·Xiaojuan QieChunling Ma
Jun 23, 2018·Brain Structure & Function·Michael Ohene-NyakoT Celeste Napier
Oct 24, 2020·Cellular and Molecular Neurobiology·Simon CoulyTsung-Ping Su
Jul 28, 2019·Frontiers in Neuroendocrinology·Josep Moreno-Rius
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun-Jie ShiLi-Fang Yu
Mar 16, 2021·Experimental Biology and Medicine·Mengting KeYancheng Xu

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