PMID: 9162216Apr 1, 1996Paper

Regulation of signal transducer, GP13O and the LIF receptor in acute inflammation in vivo

Cytokine
M Geisterfer, J Gauldie

Abstract

Recently we examined the expression of the IL-6 receptor (gp80) in three different models of acute inflammation [Geisterfer et al., 1993, Cytokine 5:1]. To continue these studies, we examined the mRNA expression of signal transducing molecule, gp130, and the LIF-R as associated members of a receptor family. Rats were treated with either Freund's complete adjuvant (FA) via intraperitoneal injection, LPS via intravenous injection, or turpentine via subcutaneous injection. The levels of gp130 and LIF-R mRNA expression had a maximum 2-3-fold increase over a 24 h period. However, the time of the maximum increase differed depending on the treatment the rats received. FA treated rats had a maximum induction of gp130 mRNA levels of 2.2-fold (for the 7.5 kb transcript) and 1.3-fold (for the 9.0 kb transcript) at 12 h. LPS treated rats had a maximum increase at 3 h where message levels increased 2.5-fold (7.5 kb) and 1.2-fold (9.0 kb). Turpentine-injected rats showed little difference in gp130 mRNA levels at any time after injection compared to controls. Maximum LIF-R mRNA levels also differed depending on the type of treatment the rats received. FA-injected rats showed a 2.1-fold mRNA increase at 3 h, whereas LPS treated rats show a max...Continue Reading

Citations

Oct 11, 2007·Japanese Journal of Ophthalmology·Jun ShojiMitsuru Sawa
Apr 29, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Randeep S JawaHeinz Baumann
Jun 17, 2000·Endocrine Reviews·C J Auernhammer, S Melmed

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