Regulation of skeletal muscle blood flow during exercise in ageing humans

The Journal of Physiology
Christopher M Hearon, Frank A Dinenno

Abstract

The regulation of skeletal muscle blood flow and oxygen delivery to contracting skeletal muscle is complex and involves the mechanical effects of muscle contraction; local metabolic, red blood cell and endothelium-derived substances; and the sympathetic nervous system (SNS). With advancing age in humans, skeletal muscle blood flow is typically reduced during dynamic exercise and this is due to a lower vascular conductance, which could ultimately contribute to age-associated reductions in aerobic exercise capacity, a primary predictor of mortality in both healthy and diseased ageing populations. Recent findings have highlighted the contribution of endothelium-derived substances to blood flow control in contracting muscle of older adults. With advancing age, impaired nitric oxide availability due to scavenging by reactive oxygen species, in conjunction with elevated vasoconstrictor signalling via endothelin-1, reduces the local vasodilatory response to muscle contraction. Additionally, ageing impairs the ability of contracting skeletal muscle to blunt sympathetic vasoconstriction (i.e. 'functional sympatholysis'), which is critical for the proper regulation of tissue blood flow distribution and oxygen delivery, and could further ...Continue Reading

References

Feb 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·J WahrenB Pernow
Nov 1, 1995·The American Journal of Physiology·D T Kurjiaka, S S Segal
Dec 1, 1993·Journal of Hypertension·W G HaynesD J Webb
Apr 1, 1994·Acta Physiologica Scandinavica·G MagnussonB Saltin
Mar 1, 1994·Journal of Cellular Physiology·M S GoligorskyW F Bahou
Oct 1, 1993·Journal of Applied Physiology·R S RichardsonP D Wagner
Apr 1, 1997·The American Journal of Physiology·W T McCulloughM L Ellsworth
Jul 9, 1998·Journal of Applied Physiology·D N ProctorM J Joyner
Jun 11, 1999·The American Journal of Physiology·G Rådegran, B Saltin
Apr 12, 2000·Acta Physiologica Scandinavica·M J Joyner, J R Halliwill
Jun 4, 2002·The Journal of Physiology·Michael E TschakovskyMichael J Joyner
Sep 11, 2002·Circulation·Frank A DinennoMichael J Joyner
Jan 28, 2003·Journal of Applied Physiology·David N ProctorUrs A Leuenberger
Feb 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·J G PooleR S Richardson
May 10, 2003·American Journal of Physiology. Heart and Circulatory Physiology·L LawrensonR S Richardson
Jun 26, 2003·The Journal of Physiology·Dennis W KochDavid N Proctor
Jul 29, 2003·Journal of Applied Physiology·David N ProctorUrs A Leuenberger
Aug 19, 2003·Journal of Applied Physiology·Jaya B RosenmeierMichael J Joyner
Oct 30, 2003·Journal of Vascular Research·Kim A DoraChris J Garland
Jan 7, 2004·Medicine and Science in Sports and Exercise·Mary L Ellsworth
Apr 6, 2004·Medicine and Science in Sports and Exercise·David N ProctorUrs A Leuenberger
Jun 29, 2004·Journal of Applied Physiology·Philip S Clifford, Ylva Hellsten
Jul 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Frank A Dinenno, Michael J Joyner
Sep 27, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Anthony J DonatoRussell S Richardson
Oct 5, 2006·Medicine and Science in Sports and Exercise·David Walter Wray, Russell S Richardson
Dec 2, 2006·The Journal of Physiology·William G SchrageMichael J Joyner

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Citations

Feb 16, 2016·Free Radical Biology & Medicine·Joel D TrinityRussell S Richardson
Apr 16, 2016·The Journal of Physiology·Ylva Hellsten
Apr 16, 2016·The Journal of Physiology·Giovanni E Mann
May 17, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Erik J Behringer, Steven S Segal
Apr 30, 2017·Medicine and Science in Sports and Exercise·Robert D Meade, Glen P Kenny
Nov 9, 2017·Frontiers in Pharmacology·Robert M Rapoport, Daphne Merkus
Nov 11, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kurt J SmithDaniel J Green
Apr 23, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Sebastien HayozWilliam F Jackson
Jul 2, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Steven A RomeroCraig G Crandall
Nov 1, 2017·Critical Reviews in Clinical Laboratory Sciences·Rayan Khaddaj MallatAndrew P Braun
Oct 4, 2017·Journal of Applied Physiology·Nicholas T KruseDarren P Casey
Aug 2, 2018·The American Journal of Sports Medicine·Evi WezenbeekErik Witvrouw
Jun 23, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Corey R HartRussell S Richardson
Nov 10, 2018·Journal of Applied Physiology·Matthew J Socha, Steven S Segal
Jun 8, 2018·Journal of Applied Physiology·Daniela Nowak-FlückJames P Fisher
Nov 30, 2018·Medicine and Science in Sports and Exercise·David M HurleyJill M Slade
May 8, 2019·Scandinavian Cardiovascular Journal : SCJ·Joakim NordanstigLennart Jivegård
Nov 9, 2017·Journal of Exercise Rehabilitation·Kwang-Seok Hong, Kijeong Kim
Dec 31, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Jacqueline K LimbergJaume Padilla
Aug 22, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Joshua M BockDarren P Casey
Nov 21, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wesley J TuckerMichael D Nelson
Jul 12, 2020·Medicina·Francesco AmendolaNicola Zingaretti
May 14, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Corinna ServienteLacy M Alexander
Apr 20, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Allan Robson Kluser SalesCarlos Eduardo Negrão
Dec 8, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sebastiaan DalleKatrien Koppo
Sep 11, 2020·Medicine and Science in Sports and Exercise·Jasdeep KaurPaul J Fadel
Apr 15, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Nour W GhonaimChristopher G Ellis
Jun 4, 2021·Journal of Applied Physiology·Jorge Pérez-GómezYlva Hellsten

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