Regulation of skeletal muscle mitochondrial activity by thyroid hormones: focus on the "old" triiodothyronine and the "emerging" 3,5-diiodothyronine

Frontiers in Physiology
A LombardiFernando Goglia

Abstract

3,5,3'-Triiodo-L-thyronine (T3) plays a crucial role in regulating metabolic rate and fuel oxidation; however, the mechanisms by which it affects whole-body energy metabolism are still not completely understood. Skeletal muscle (SKM) plays a relevant role in energy metabolism and responds to thyroid state by remodeling the metabolic characteristics and cytoarchitecture of myocytes. These processes are coordinated with changes in mitochondrial content, bioenergetics, substrate oxidation rate, and oxidative phosphorylation efficiency. Recent data indicate that "emerging" iodothyronines have biological activity. Among these, 3,5-diiodo-L-thyronine (T2) affects energy metabolism, SKM substrate utilization, and mitochondrial functionality. The effects it exerts on SKM mitochondria involve more aspects of mitochondrial bioenergetics; among these, respiratory chain activity, mitochondrial thermogenesis, and lipid-handling are stimulated rapidly. This mini review focuses on signaling and biochemical pathways activated by T3 and T2 in SKM that influence the above processes. These novel aspects of thyroid physiology could reveal new perspectives for understanding the involvement of SKM mitochondria in hypo- and hyper-thyroidism.

References

Jul 7, 1995·The Journal of Biological Chemistry·C WrutniakJ Ghysdael
Aug 7, 1996·Biochimica Et Biophysica Acta·D F Rolfe, M D Brand
Oct 29, 1997·Journal of Molecular Endocrinology·S G BallW W Chin
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·B M JuckerG I Shulman
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P BarbeD Langin
Feb 15, 2001·Journal of Molecular Endocrinology·C Wrutniak-CabelloG Cabello
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·K R ShortK S Nair
Sep 7, 2001·The Journal of Clinical Investigation·V LebonG I Shulman
Sep 12, 2001·Trends in Endocrinology and Metabolism : TEM·D Knutti, A Kralli
Jan 10, 2002·Nature·Karim S EchtayMartin D Brand
Feb 6, 2002·Genome Research·Karine ClémentDominique Langin
Feb 28, 2002·Journal of Bioenergetics and Biomembranes·Véronique NogueiraXavier M Leverve
Feb 20, 2003·Archives of Biochemistry and Biophysics·Paola VendittiSergio Di Meo
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fernando Goglia, Vladimir P Skulachev
Dec 18, 2004·Journal of Cellular Physiology·L BahiR Ventura-Clapier
Feb 16, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P Puigserver
Jul 15, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Antonia LanniFernando Goglia
Aug 16, 2005·Cell Metabolism·Martin D Brand, Telma C Esteves
Mar 31, 2007·Archives of Biochemistry and Biophysics·P VendittiS Di Meo
Jul 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sibylle JägerBruce M Spiegelman
Oct 27, 2007·Journal of Applied Physiology·Isabella IrrcherDavid A Hood
Apr 24, 2008·American Journal of Physiology. Endocrinology and Metabolism·Elena SilvestriMaria Moreno
May 13, 2008·Biochimica Et Biophysica Acta·Assunta LombardiFernando Goglia
Aug 2, 2008·Journal of Applied Physiology·D J BranvoldW W Winder
Sep 5, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Adamo ValleJordi Oliver
May 23, 2009·PloS One·François CasasChantal Wrutniak-Cabello
Jul 25, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Graham P HollowayArend Bonen
Apr 7, 2010·The Journal of Biological Chemistry·Assunta LombardiFernando Goglia
May 11, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Federica CioffiFernando Goglia
Jun 15, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria MorenoFernando Goglia

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Citations

Sep 28, 2016·Thyroid : Official Journal of the American Thyroid Association·Lies LangoucheGreet Van den Berghe
Sep 21, 2016·The Journal of Physiology·Christopher L RileyEdward M Mills
Jan 23, 2016·Food & Function·Guoyao Wu
Oct 21, 2017·The Journal of Endocrinology·Flavia F BloiseTania Maria Ortiga-Carvalho
Feb 16, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Martina E SchmidtKaren Steindorf
Jul 13, 2016·The Journal of Experimental Biology·Rob S JamesFrank Seebacher
Jul 4, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Lingyan Chen, Yu Hu
Oct 12, 2019·International Journal of Molecular Sciences·Yu-Chin LiuKwang-Huei Lin
Aug 28, 2020·The Journal of Physiology·Evani Patel, Ramsey Smith
Oct 17, 2018·Frontiers in Cell and Developmental Biology·Isabelle Bourdeau JulienPaul A Dutchak
Dec 29, 2020·Head & Neck·Samer T ElsamnaBoris Paskhover
Apr 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katie L DaviesEmily J Camm

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