Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Carlo O MartinezPaula K Shireman

Abstract

Muscle regeneration requires CC chemokine receptor 2 (CCR2) expression on bone marrow-derived cells; macrophages are a prominent CCR2-expressing cell in this process. CCR2-/- mice have severe impairments in angiogenesis, macrophage recruitment, and skeletal muscle regeneration following cardiotoxin (CTX)-induced injury. However, multiple chemokines activate CCR2, including monocyte chemotactic proteins (MCP)-1, -3, and -5. We hypothesized that MCP-1 is the chemokine ligand that mediates the impairments present in CCR2-/- mice. We examined muscle regeneration, capillary density, and cellular recruitment in MCP-1-/- and CCR2-/- mice following injury. Muscle regeneration and adipocyte accumulation, but not capillary density, were significantly impaired in MCP-1-/- compared with wild-type (WT) mice; however, muscle regeneration and adipocyte accumulation impairments were not as severe as observed in CCR2-/- mice. Although tissue levels of MCP-5 were elevated in MCP-1-/- mice compared with WT, the administration of MCP-5 neutralizing antibody did not alter muscle regeneration in MCP-1-/- mice. While neutrophil accumulation after injury was similar in all three mouse strains, macrophage recruitment was highest in WT mice, intermediat...Continue Reading

References

May 17, 1996·The Journal of Biological Chemistry·T Kurihara, R Bravo
Oct 16, 1996·Journal of Immunological Methods·E Lagasse, I L Weissman
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·W A KuzielN Maeda
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shannon L McKinney-FreemanMargaret A Goodell
Apr 15, 2003·Trends in Cardiovascular Medicine·Atsushi Asakura
Jan 13, 2004·Physiological Reviews·Sophie B P Chargé, Michael A Rudnicki
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·J B Harris
Oct 30, 2004·Circulation Research·Israel F Charo, Mark B Taubman
Dec 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Herbert SpringRuth Ganss
Jan 21, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mukesh SummanPetia P Simeonova
Feb 10, 2006·The New England Journal of Medicine·Israel F Charo, Richard M Ransohoff
Feb 21, 2006·The Journal of Surgical Research·Paula K ShiremanLinda M McManus
Mar 18, 2006·American Journal of Respiratory Cell and Molecular Biology·Bethany B MooreGalen B Toews
Aug 11, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Peter S ZammitZipora Yablonka-Reuveni
Oct 6, 2006·American Journal of Physiology. Cell Physiology·Verónica Contreras-ShannonPaula K Shireman
Dec 1, 2006·Journal of Leukocyte Biology·Paula K ShiremanLinda M McManus
Mar 17, 2007·The Journal of Clinical Investigation·Chia-Lin TsouIsrael F Charo
Mar 28, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Bruno PéaultJohnny Huard
May 9, 2007·The Journal of Experimental Medicine·Ludovic ArnoldBénédicte Chazaud
May 25, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Oscar OchoaPaula K Shireman
Sep 22, 2007·Journal of Leukocyte Biology·Jean M DaleyJorge E Albina
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Fernando Oneissi MartinezMassimo Locati
Oct 2, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dongxu SunPaula K Shireman

❮ Previous
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Citations

Nov 16, 2013·Experimental & Molecular Medicine·In Kap KoJames J Yoo
Jun 24, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Haiyan LuLan Zhou
Nov 26, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew J McHalePaula K Shireman
Mar 3, 2012·Journal of Applied Physiology·Shohei KohnoTakeshi Nikawa
Dec 21, 2013·BMC Musculoskeletal Disorders·Claude H CôtéElise Duchesne
Jul 30, 2011·Skeletal Muscle·Christopher J MannPura Muñoz-Cánoves
Apr 30, 2014·BioMed Research International·Laura Cristina CeafalanMihail Eugen Hinescu
Dec 7, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Jessica H Spahn, Daniel Kreisel
Sep 29, 2011·The Journal of Cell Biology·Michelle J DoyleBradley B Olwin
Dec 23, 2015·Ageing Research Reviews·Carla Domingues-FariaStephane Walrand
Feb 7, 2013·The FEBS Journal·Marielle SaclierBénédicte Chazaud
Apr 5, 2016·Ageing Research Reviews·Jasdeep SainiNasser Al-Shanti
Aug 15, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Caitlin M FearingPaula K Shireman
Feb 15, 2014·The American Journal of Pathology·Hanzhou WangPaula K Shireman
Nov 5, 2013·Biochemical and Biophysical Research Communications·Noriaki KawanishiKatsuhiko Suzuki
Oct 5, 2013·The American Journal of Pathology·Margaret L Novak, Timothy J Koh
May 27, 2014·BioMed Research International·Elena RigamontiSilvia Brunelli
Mar 19, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kelsey H CollinsWalter Herzog
Mar 26, 2014·Innate Immunity·Jennifer NicholasBarbara St Pierre Schneider
Feb 7, 2017·Nature Reviews. Immunology·James G Tidball
Jul 14, 2017·Exercise and Sport Sciences Reviews·Erik P Rader, Brent A Baker
Aug 3, 2018·Antioxidants & Redox Signaling·Francesca De SantaElisabetta Ferraro
Aug 31, 2018·International Immunology·Yumiko Oishi, Ichiro Manabe
Aug 22, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ying WangJames G Tidball
Dec 4, 2015·Nature Communications·Ludovic ArnoldChristophe Combadiere
Jan 2, 2013·American Journal of Physiology. Endocrinology and Metabolism·Nicolas J PillonAmira Klip
Jan 10, 2019·Journal of Clinical Periodontology·Reinhard Gruber
Feb 14, 2015·Journal of Applied Physiology·David W HammersRoger P Farrar
Aug 10, 2019·Stem Cells International·Junio DortNicolas A Dumont
Aug 15, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·André Luis Araujo MinariRonaldo Vagner Thomatieli-Santos
Jan 27, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martina VeldersPatrick Diel
Aug 22, 2013·Journal of Leukocyte Biology·Heather B Cohen, David M Mosser
Aug 21, 2019·BMC Research Notes·Marie-Pier RousselElise Duchesne
Oct 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing ZhangJie Du

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