Regulation of sperm flagellar motility by calcium and cAMP-dependent phosphorylation

Journal of Cellular Biochemistry
C J Brokaw

Abstract

There is substantial evidence that cAMP-dependent phosphorylation is involved in the activation of motility of spermatozoa as they are released from storage in the male reproductive tract. This evidence includes observations that in vivo activation of motility can be inhibited by protein kinase inhibitors, can be reversed by protein phosphatase treatment of demembranated spermatozoa, and is associated with phosphorylation of sperm proteins, and observations that spermatozoa that have not been activated in vivo can be activated in vitro by cAMP-dependent phosphorylation. Activation in vivo can often be triggered by conditions that increase intracellular pH, but the relevance of this to in vivo activation under natural conditions and the steps between pH increase and cAMP increase have not been fully established. The relationships between changes in the protein substrates for cAMP-dependent phosphorylation and changes in axonemal function are still unknown. Sperm chemotaxis to egg secretions is widespread; in the sea urchin Arbacia, the egg jelly peptide resact has been identified as a chemoattractant. Response to chemoattractants involves changes in asymmetry of flagellar bending waves, and similar changes in asymmetry can be pr...Continue Reading

References

Jan 1, 1979·The Journal of Cell Biology·S F Goldstein
Nov 1, 1977·Biophysical Journal·H C Berg, E M Purcell
Feb 15, 1985·Science·G E WardV D Vacquier
Oct 1, 1985·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·E W Stommel, R E Stephens
Jul 31, 1986·Biochemical and Biophysical Research Communications·J K BentleyC Van Dop
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J TezonC W Bardin
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J S TrimmerV D Vacquier
Jan 1, 1986·Annual Review of Cell Biology·J S Trimmer, V D Vacquier
Jan 1, 1987·Cell Motility and the Cytoskeleton·D Eshel, C J Brokaw
Dec 1, 1985·The Journal of Cell Biology·G E WardV D Vacquier
Jun 1, 1985·The Journal of Cell Biology·C J Brokaw, S M Nagayama
Feb 1, 1974·Journal of Cellular Physiology·C J Brokaw
Jun 4, 1974·Biochemical and Biophysical Research Communications·C J BrokawL Bobrow
Jan 1, 1984·Annals of the New York Academy of Sciences·C J Brokaw
Jan 1, 1982·Progress in Clinical and Biological Research·C J Brokaw
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D F BabcockH A Lardy
Feb 1, 1984·Developmental Biology·T BibringC C Harter
Jan 1, 1980·The Journal of Cell Biology·B H Gibbons
Jan 1, 1980·The Journal of Cell Biology·B H Gibbons, I R Gibbons

❮ Previous
Next ❯

Citations

Jan 1, 1989·The International Journal of Biochemistry·T Vanha-Perttula, J Kasurinen
Feb 11, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·K AshizawaY Tsuzuki
Feb 1, 1989·Current Opinion in Cell Biology·U W Goodenough
Jan 12, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·K AshizawaY Tsuzuki
Nov 1, 1990·The Journal of Cell Biology·L H BookbinderV D Vacquier
Jun 1, 1994·The Journal of Cell Biology·S L Tamm, M Terasaki
Dec 1, 1994·The Journal of Cell Biology·D R HowardW S Sale
Jun 7, 2011·Molecular Human Reproduction·Yuriy Kirichok, Polina V Lishko
Apr 10, 2008·Biological Reviews of the Cambridge Philosophical Society·Michael Werner, Leigh W Simmons
Jan 1, 1991·Annals of the New York Academy of Sciences·P Olds-Clarke
Sep 1, 1993·American Journal of Respiratory Cell and Molecular Biology·M SalatheA Wanner
Mar 30, 2005·Zoological Science·Kogiku ShibaShoji A Baba
Sep 25, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Fei QuZhide Ding
Feb 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Carol A VinesGary N Cherr
Oct 25, 2011·Annual Review of Physiology·Polina V LishkoDavid E Clapham
Jun 13, 2001·The Journal of Cell Biology·P YangW S Sale
Apr 20, 2001·The Journal of Cell Biology·A R GaillardW S Sale
Jan 1, 1990·Archives of Andrology·G C MajumderM Barua
Sep 14, 2007·Archives of Andrology·Yibing HanHuai L Feng
Oct 16, 2015·Systems Biology in Reproductive Medicine·Brett R Lackey, Sandra L Gray
Sep 13, 2016·Journal of Ginseng Research·Sandra L GrayWilliam R Boone
Oct 1, 2004·Molecular Reproduction and Development·Steve TardifJanice L Bailey
Jul 30, 2014·Biochimica Et Biophysica Acta·Victor D VacquierCarmen Beltrán
Apr 4, 2009·Cell Motility and the Cytoskeleton·Shuichi Hayashi, Chikako Shingyoji
Apr 24, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Zhao NamulaTakeshige Otoi
Jul 1, 1996·The Tohoku Journal of Experimental Medicine·P M Zavos, P N Zarmakoupis-Zavos
Jul 18, 2006·Developmental Biology·Fang XieMarco Conti
Jul 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·João P MonteiroBranca M Silva
Jun 6, 2009·International Review of Cell and Molecular Biology·Albrecht StenzingerMonika Wimmer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.