PMID: 7541468Apr 15, 1995Paper

Regulation of spontaneous phasic firing of rat supraoptic vasopressin neurones in vivo by glutamate receptors

The Journal of Physiology
R NissenL P Renaud

Abstract

1. Vasopressin-secreting neurones in the rat hypothalamic supraoptic nucleus display patterned spontaneous phasic activity, which is apparently maintained in vivo through yet unidentified neurotransmitter system(s). The present investigation used extracellular recording techniques in anaesthetized Long-Evans rats to evaluate whether the neurotransmitter mechanism underlying phasic firing is provided via a family of ionotropic glutamate receptors. 2. N-Methyl-D-aspartate (NMDA) reliably evoked bursts of activity in twenty-seven of twenty-eight phasic neurones. Amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) and kainate also elicited pronounced excitations in twenty-one of twenty-one and and fourteen of fifteen phasic cells, respectively. 3. A rapid blockade of on-going phasic activity was consistently induced following brief applications of both NMDA and non-NMDA receptor antagonists; extended application of antagonists resulted in prolonged silent periods, during which phasic activity failed to recur for minutes. Neither saline nor a cholecystokinin receptor antagonist influenced cell firing. 4. In contrast to putative vasopressin cells, application of NMDA receptor ligands did not affect the spontaneous activity in ...Continue Reading

Citations

Sep 17, 2005·The Journal of Physiology·G S BhumbraR E J Dyball
May 18, 2004·The Journal of Physiology·Nancy SabatierGareth Leng
Oct 13, 2007·The Journal of Physiology·William E Armstrong
Jul 1, 1997·The European Journal of Neuroscience·N HussyM G Desarménien
Jul 27, 2014·The Journal of Physiology·Linda A MortonJeffrey G Tasker
Jan 26, 2002·Microscopy Research and Technique·C Wook Pak, Margarita C Currás-Collazo
Feb 4, 2010·The Journal of Physiology·Ion R PopescuJeffrey G Tasker
Jul 22, 2006·The Journal of Physiology·Grant R J Gordon, Jaideep S Bains
Mar 10, 2010·Journal of Neuroendocrinology·W E ArmstrongR Teruyama
Dec 7, 2005·Trends in Neurosciences·Colin H Brown, Charles W Bourque
May 27, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mike Ludwig, Javier Stern
May 21, 2015·Biophysical Journal·Kaiyu Zheng, Dmitri A Rusakov
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Jun 9, 2004·The European Journal of Neuroscience·Colin H BrownCharles W Bourque
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Feb 14, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cherif Boudaba, Jeffrey G Tasker
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Aug 19, 2000·American Journal of Physiology. Endocrinology and Metabolism·R Meeker, A Fernandes
Jun 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Javier E Stern, Evgeniy S Potapenko

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