Regulation of Src homology 2-containing tyrosine phosphatase 1 during activation of human neutrophils. Role of protein kinase C.

The Journal of Biological Chemistry
J H BrumellG P Downey

Abstract

The tyrosine phosphorylation of several proteins induced in neutrophils by soluble and particulate stimuli is thought to be crucial for initiating antimicrobial responses. Although activation of tyrosine kinases is thought to mediate this event, the role of tyrosine phosphatases in the initiation and modulation of neutrophil responses remains largely undefined. We investigated the role of Src homology 2-containing tyrosine phosphatase 1 (SHP-1; also known as protein tyrosine phosphatase 1C (PTP1C), hematopoetic cell phosphatase, PTP-N6, and SHPTP-1), a phosphatase expressed primarily in hemopoietic cells, in the activation of human neutrophils. SHP-1 mRNA and protein were detected in these cells, and the enzyme was found to be predominantly localized to the cytosol in unstimulated cells. Following stimulation with neutrophil agonists such as phorbol ester, chemotactic peptide, or opsonized zymosan, a fraction of the phosphatase redistributed to the cytoskeleton. Agonist treatment also induced significant decreases (30-60%) in SHP-1 activity, which correlated temporally with increases in the cellular phosphotyrosine content. Phosphorylation of SHP-1 on serine residues was associated with the inhibition of its enzymatic activity,...Continue Reading

References

Mar 16, 1992·Biochemical and Biophysical Research Communications·T KusunokiH Mikawa
Oct 30, 1992·Biochemical and Biophysical Research Communications·D Hecht, Y Zick
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J PlutzkyR D Rosenberg
Aug 15, 1989·Biochemical and Biophysical Research Communications·J Gomez-CambroneroR I Sha'afi
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J S Gutkind, K C Robbins
Mar 15, 1988·Biochemical and Biophysical Research Communications·C K HuangJ E Casnellie
Jun 1, 1995·Current Opinion in Immunology·M Okumura, M L Thomas
Aug 4, 1995·The Journal of Biological Chemistry·A YetterL C Platanias
Dec 1, 1994·The American Journal of Physiology·J H Brumell, S Grinstein
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·P PeraldiE Van Obberghen
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·Z ZhaoE H Fischer
Jan 14, 1994·Biochemical and Biophysical Research Communications·P E McGregorJ D Edwards
Sep 1, 1993·The Journal of Clinical Investigation·H SengeløvN Borregaard
Jan 19, 1996·The Journal of Biological Chemistry·J H BrumellS Grinstein
Aug 1, 1991·Trends in Cell Biology·R Schreck, P A Baeuerle

❮ Previous
Next ❯

Citations

Jan 9, 2001·Journal of Cellular Physiology·R S LabowJ P Santerre
Feb 8, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Anna Bertram, Klaus Ley
Oct 18, 2003·Seminars in Immunology·Shida Yousefi, Hans-Uwe Simon
Oct 13, 2000·British Journal of Pharmacology·H Y SohnU Pohl
Apr 5, 2011·The Journal of Biological Chemistry·Julie ToubianaJean-Daniel Chiche
Nov 26, 2010·Molecular & Cellular Proteomics : MCP·Gregory C LuermanKenneth R McLeish
Apr 24, 2002·Antioxidants & Redox Signaling·Luminita Pricop, Jane E Salmon
Nov 19, 2005·American Journal of Respiratory Cell and Molecular Biology·Theo J MoraesGregory P Downey
Jun 23, 2009·Pediatric Research·Ramachandran RashmiJoyce M Koenig
Dec 5, 2006·Ageing Research Reviews·Cosimo TortorellaSalvatore Antonaci
May 20, 2003·Immunological Reviews·Hans-Uwe Simon
Dec 27, 2006·Free Radical Biology & Medicine·Lea FialkowGregory P Downey
Jul 16, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sen Rong YanAndrew C Issekutz
May 31, 2001·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·C M Doerschuk
Jan 17, 2002·The Journal of Biological Chemistry·Yuan LiuCharles A Parkos
Jun 14, 2017·Journal of Leukocyte Biology·Clare L Abram, Clifford A Lowell
Apr 27, 2001·The Journal of Biological Chemistry·G Craggs, S Kellie
Jan 27, 1998·The Journal of Biological Chemistry·M GlogauerC A McCulloch
Jul 23, 2004·The Journal of Biological Chemistry·Matthew L JonesAlastair W Poole
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Nusrat SharifLionel B Ivashkiv
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J KrugerG P Downey
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E Rollet-LabelleP H Naccache
Oct 23, 1997·Biochemical and Biophysical Research Communications·K AsahiN Takahashi
Sep 26, 2003·Biochimica Et Biophysica Acta·Lars Neisig MøllerJens Juul Holst

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.