Regulation of substance P release mediated via prejunctional histamine H3 receptors

European Journal of Pharmacology
T OhkuboH Takahashi

Abstract

The involvement of the histamine H3 receptor in the regulation of substance P release in neurogenic inflammation was studied by using rat hindpaw skin. R-(-)-alpha-Methylhistamine, a specific histamine H3 receptor agonist, significantly inhibited the increased vascular permeability induced by antidromic electrical stimulation of the sciatic nerve in a dose-dependent manner at doses of 0.5-3 mg/kg (i.v.), and thioperamide (2 mg/kg i.p.), a specific histamine H3 receptor antagonist, prevented the inhibitory effect of R-(-)-alpha-methylhistamine. The antidromic stimulation also caused a significant increase in immunoreactive substance P release in the subcutaneous (s.c.) perfusate in the rat hindpaw. R-(-)-alpha-Methylhistamine (0.25-2 mg/kg) dose dependently inhibited the increase in release of immunoreactive substance P, and thioperamide (2 mg/mg i.p.) antagonized it. Perfusion of histamine (10(-3) M) elicited a significant increase of immunoreactive substance P release in the perfusate, which was reduced by R-(-)-alpha-methylhistamine and the antagonism of thioperamide was also observed. Histamine (in the presence of histamine H1 and H2 receptor antagonists) had an inhibitory effect on the electrically evoked release of immunor...Continue Reading

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D StrettonP J Barnes
Jun 1, 1991·Journal of Autonomic Pharmacology·C A Maggi
May 1, 1990·Trends in Pharmacological Sciences·P J BarnesD F Rogers
Sep 23, 1987·European Journal of Pharmacology·N Frossard, P J Barnes
May 1, 1989·British Journal of Pharmacology·M IchinoseP J Barnes
Dec 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·E SchlickerM Göthert
May 14, 1987·Nature·J M ArrangJ C Schwartz
Aug 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·M C Koss, J A Hey
Jan 1, 1960·Medicina Experimentalis. International Journal of Experimental Medicine·M ROCHA E SILVA, A ANTONIO

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Citations

Dec 17, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P RzodkiewiczS Maslinski
Jun 14, 2001·Current Pain and Headache Reports·A A Larson, K J Kovács
Oct 18, 2000·European Journal of Pharmacology·A D KraneveldF P Nijkamp
Jan 5, 2002·European Journal of Pharmacology·Shinobu SakuradaTsukasa Sakurada
Jun 12, 2003·European Journal of Pharmacology·Keri E CannonLindsay B Hough
Apr 18, 1997·European Journal of Pharmacology·P R GermonpréR A Pauwels
Dec 14, 2002·Pharmacology, Biochemistry, and Behavior·Shinobu SakuradaTsukasa Sakurada
May 30, 2002·Progress in Neurobiology·Mark J Millan
Feb 11, 1998·General Pharmacology·P Holzer
Sep 20, 2001·International Immunopharmacology·A D Kraneveld, F P Nijkamp
Oct 14, 2003·International Immunopharmacology·Maria Alejandra HossenChiaki Kamei
Apr 27, 2000·Allergy·G F JoosR A Pauwels
Jul 10, 2001·Journal of Veterinary Pharmacology and Therapeutics·S R Bailey, F M Cunningham
Nov 1, 1995·British Journal of Pharmacology·P HolzerB A Peskar
Sep 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Lindsay B Hough, Frank L Rice
Dec 2, 2008·Biological & Pharmaceutical Bulletin·Kerstin SanderHolger Stark
Jun 5, 2007·European Journal of Pharmacology·Md Ashequr RahmanChiaki Kamei
Nov 22, 2005·Dermatologic Therapy·Joanna Wallengren
Aug 23, 2003·The British Journal of Dermatology·Y Ashida, M Denda
Mar 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y SugimotoC Kamei
Apr 2, 2003·Journal of Veterinary Pharmacology and Therapeutics·A P Foster, F M Cunningham
Jul 11, 2012·Journal of Neurochemistry·Anayansi Molina-HernándezJosé-Antonio Arias-Montaño
Mar 18, 2005·The Journal of Pain : Official Journal of the American Pain Society·Keri E Cannon, Lindsay B Hough
Jun 22, 2011·Neuroscience·K RossbachW Bäumer
Aug 11, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·H Kashiba, E Senba
Oct 11, 2008·Journal of Pharmacological Sciences·Emiko YokotaChiaki Kamei
Apr 11, 2006·Journal of Pharmacological Sciences·Maria Alejandra HossenChiaki Kamei
Oct 19, 2016·Molecular Pharmacology·Gustavo Nieto-AlamillaJosé-Antonio Arias-Montaño
Apr 13, 2001·Microscopy Research and Technique·D J Williamson, R J Hargreaves
Jan 4, 2012·International Archives of Allergy and Immunology·Peter Daley-YatesBarbara McQuade
Jan 24, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Ioannis GoutosPatricia M Richardson
Sep 2, 2017·Headache·Hsiangkuo Yuan, Stephen D Silberstein

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