PMID: 4899873Jul 1, 1969Paper

Regulation of sugar transport in isolated bacterial membrane preparations from Escherichia coli

Proceedings of the National Academy of Sciences of the United States of America
H R Kaback

Abstract

The experiments presented in this paper demonstrate that glucose transport via the phosphoenolpyruvate-phosphotransferase system as studied in isolated E. coli membrane preparations is subject to regulation by sugar-P's. Glucose transport in these preparations is inhibited by glucose-6-P, glucose-1-P, and, to a lesser extent, by other P-esters. There appear to be two inhibitory sites, one specific for glucose-1-P and related sugar-1-P's and the other specific for glucose-6-P and related sugar-6-P's. The inhibition by these sugar-P's is noncompetitive, and the inhibitory sites are separate, subject to independent control, and apparently are accessible from outside the membrane. Furthermore, glucose-6-P is able to reverse partially inhibition of glucose transport by glucose-1-P and vice versa. Preliminary evidence is presented indicating that glucose-1-P may play a central role in the regulation of sugar transport in general, by virtue of its ability to inhibit selectively the transport of sugars other than glucose.

References

Jan 1, 1968·Advances in Enzyme Regulation·E R StadtmanJ S Hubbard
Jun 1, 1969·Archives of Biochemistry and Biophysics·H R Kaback, F Deuel
Apr 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·H R Kaback, E R Stadtman
Oct 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·W KUNDIGS ROSEMAN

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Citations

Jun 27, 2007·Biotechnology and Bioengineering·Christophe ChassagnoleMatthias Reuss
Mar 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·L S Milner, H R Kaback
Jul 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·H R Kaback, L S Milner
Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M EsfahaniS J Wakil
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D C Quinlan, J Hochstadt
Jun 20, 1972·Annals of the New York Academy of Sciences·H R Kaback
Feb 2, 1971·Biochimica Et Biophysica Acta·W G KnipprathC F Allen
Oct 25, 1973·Biochimica Et Biophysica Acta·G van Thienen, P W Postma
Jul 1, 1974·Archives of Biochemistry and Biophysics·E M Barnes
Oct 20, 2004·Metabolic Engineering·Diana VisserJoseph J Heijnen
Dec 3, 1971·Biochimica Et Biophysica Acta·J Singer, E Englesberg
Apr 1, 1973·FEBS Letters·M A TarshisL F Panchenko
Mar 1, 1984·Biotechnology and Bioengineering·M M DomachM L Shuler
Jun 1, 1972·Annals of the New York Academy of Sciences·H R Kaback
May 1, 1971·Journal of Bacteriology·R P Schneider, W R Wiley
Sep 1, 1985·Microbiological Reviews·P W Postma, J W Lengeler
Jan 1, 1971·Journal of Bacteriology·D Berkowitz
Sep 1, 1993·Microbiological Reviews·P W PostmaG R Jacobson
Dec 6, 1974·Science·H R Kaback

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