PMID: 8584199Aug 11, 1995Paper

Regulation of synapse density by 5-HT2A receptor agonist and antagonist in the spinal cord of chicken embryo

Neuroscience Letters
Y NiitsuN Okado

Abstract

Identification of mechanisms that regulate the number of synapses in the brain has been a key issue for understanding the mechanism of plasticity. Here, we report that the density of synapses can be changed using an antagonist and/or an agonist of serotonin (5-HT) type 2A receptors in the chicken spinal cord. Because of the widespread distribution pattern of 5-HT fibers and 5-HT2A receptors in the central nervous system, 5-HT is thought to play a role in the formation and maintenance of synapses that are involved in normal brain function and mechanism of plasticity.

Citations

Dec 13, 2000·Brain Research. Brain Research Reviews·D O Frost, J L Cadet
Nov 7, 1998·Brain Research. Developmental Brain Research·K HayashiT Shirao
Oct 2, 1998·Neuroscience Letters·T MaeshimaN Okado
Nov 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kelly A JonesPeter Penzes
Jun 20, 2008·Journal of Neurophysiology·Vatsala Thirumalai, Hollis T Cline
Jun 23, 2009·General and Comparative Endocrinology·Yupaporn ChaisehaMohamed E El Halawani
Nov 30, 2004·Neuroscience Research·Toru MaeshimaNobuo Okado
Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A HayashiN Okado
Sep 1, 2017·Journal of Psychopharmacology·R L Carhart-Harris, D J Nutt
Nov 12, 2020·Journal of Psychopharmacology·Ari Brouwer, Robin Lester Carhart-Harris

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