Regulation of synaptic functions in central nervous system by endocrine hormones and the maintenance of energy homoeostasis.

Bioscience Reports
Zhiping P Pang, Weiping Han

Abstract

Energy homoeostasis, a co-ordinated balance of food intake and energy expenditure, is regulated by the CNS (central nervous system). The past decade has witnessed significant advances in our understanding of metabolic processes and brain circuitry which responds to a broad range of neural, nutrient and hormonal signals. Accumulating evidence demonstrates altered synaptic plasticity in the CNS in response to hormone signals. Moreover, emerging observations suggest that synaptic plasticity underlies all brain functions, including the physiological regulation of energy homoeostasis, and that impaired synaptic constellation and plasticity may lead to pathological development and conditions. Here, we summarize the current knowledge on the regulation of postsynaptic receptors such as AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), NMDA (N-methyl-D-aspartate) and GABA (γ-aminobutyric acid) receptors, and the presynaptic components by hormone signals. A detailed understanding of the neurobiological mechanisms by which hormones regulate energy homoeostasis may lead to novel strategies in treating metabolic disorders.

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Citations

Mar 12, 2015·Journal of Cellular Physiology·Sawsan Elattar, Ande Satyanarayana
Apr 16, 2015·Neurochemical Research·Ulrike Winkler, Johannes Hirrlinger
Jan 11, 2014·The Biochemical Journal·Yue WangWeiping Han
Oct 30, 2014·Frontiers in Neuroscience·Jackie Lau, Herbert Herzog
Sep 20, 2018·Diabetes, Obesity & Metabolism·Tiziana NapolitanoPatrick Collombat
May 4, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P SweeneyY Yang

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