PMID: 1744Dec 1, 1975

Regulation of synthesis of glutamine synthetase by adenylylated glutamine synthetase

Proceedings of the National Academy of Sciences of the United States of America
F FoorB Magasanik

Abstract

We have examined three mutants of Klebsiella aerogenes whose genetic lesions (glnB, glnD, and glnE) are in loci unlinked to the structural gene for glutamine sythetase (glnA) and in which the control of both the level and state of adenylylation of glutamine synthetase is altered. Each mutation alters a different component of the adenylylation system of glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2]. Inability of the cell to deadenylylate glutamine synthetase (glnB and glnD) greatly decreases its production, while inability to adenylylate glutamine sythetase (glnE) results in its constitutively high production. These results together with our previous results indicate that adenylylated glutamine synthetase inhibits the transcription of glnA.

References

Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·B TylerB Magasanik
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·W B AndersonE R Stadtman

Citations

Apr 20, 1995·Molecular & General Genetics : MGG·R Edwards, M J Merrick
Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E GarciaS Kustu
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R J FrinkD G Glitz
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S G RheeE R Stadtman
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F FoorB Magasanik
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S L Streicher, B Tyler
Mar 29, 2013·Animal Biotechnology·Wang Pengpeng, Zhiliang Tan
Mar 10, 2001·Microbiology and Molecular Biology Reviews : MMBR·T ArcondéguyM J Merrick
Nov 22, 1976·Biochemical and Biophysical Research Communications·W R ScowcroftJ D Pagan
Nov 22, 1976·Biochemical and Biophysical Research Communications·F J Bergersen, G L Turner
Aug 7, 2012·FEMS Microbiology Reviews·Luciano F HuergoM J Merrick
Apr 23, 2017·Applied and Environmental Microbiology·Florence MusJohn W Peters
Dec 4, 2013·Microbiology and Molecular Biology Reviews : MMBR·W C van HeeswijkFred C Boogerd
Oct 7, 2020·Journal of Breath Research·John GreenmanSaliha Saad

Related Concepts

Phosphaden
Enterobacter
Paracolobactrum
Gamma-glutamyl transferase
Cistron
Glutamate-Ammonia Ligase

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