Regulation of T-cell activation: differences among T-cell subsets

Immunological Reviews
T F GajewskiF W Fitch

Abstract

Four regulatory phenomena appear to regulate differentially the activation of TH1, TH2, and CTL clones. First, IFN-gamma selectively inhibits proliferation of TH2 but not TH1 cells; lymphokine production by TH2 cells is not affected by IFN-gamma. In addition, when fresh OVA-specific HTL clones are derived in the presence of rIL-2 TH2 cells are preferentially obtained, whereas TH1 cells predominate if cloning is performed in rIL-2 plus rIFN-gamma. These results suggest that the presence of IFN-gamma during the course of an immune response would result in the preferential expansion of HTL of the TH1 phenotype. Proliferation of CTL clones is not influenced by IFN-gamma. Second, different APC populations appear to differentially activate TH1 and TH2 clones. Purified splenic B cells stimulate optimal proliferation of TH2 but not TH1 cells, whereas macrophage/dendritic cells appear to stimulate optimal proliferation of TH1 but not TH2 cells. Since both APC types stimulate lymphokine production by each of the HTL subsets, these results suggest the existence of TH1- and TH2-specific cofactors for growth. Third, high doses of immobilized anti-CD3 mAb inhibit IL-2-dependent proliferation of TH1 but not TH2 clones. Since this effect appea...Continue Reading

References

Jun 1, 1975·Journal of Immunological Methods·W F Davidson, C R Parish
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A Kelso, N M Gough
Mar 1, 1989·The Journal of Experimental Medicine·P J MorrisseyS G Reed
Sep 1, 1988·Immunology Today·K Bottomly
Aug 1, 1986·The Journal of Experimental Medicine·R Fernandez-BotranE S Vitetta
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A H LichtmanA K Abbas
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C T WeaverE R Unanue
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P Cresswell
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K L McGuireE V Rothenberg
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R D GarmanD H Raulet
Jan 1, 1981·Immunological Reviews·A L GlasebrookF W Fitch
Nov 1, 1982·Infection and Immunity·S N VogelA D O'Brien
Aug 1, 1983·The Journal of Experimental Medicine·R ShimonkevitzH Grey
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S C MeuerE L Reinherz
Sep 1, 1983·The Journal of Experimental Medicine·S C MeuerE L Reinherz
Apr 1, 1980·The Journal of Experimental Medicine·A L Glasebrook, F W Fitch

❮ Previous
Next ❯

Citations

Sep 1, 1995·Clinical Cardiology·A M FeldmanS Murali
Mar 1, 1994·Stem Cells·S F WolfJ Sypek
Jan 1, 1990·Biotherapy·D H Schwartz, T C Merigan
Feb 1, 1997·Molecular Neurobiology·B PopkoA M Garcia
Jun 30, 2009·Intensive Care Medicine·Jean-Damien Ricard, Damien Roux
Jun 8, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Angelo CortiVanesa Gregorc
Dec 1, 1990·Molecular Immunology·R G LynchN Noben
Apr 1, 1996·Immunology Letters·S A ShiddoR Thorstensson
Aug 1, 1995·Immunology Today·A Kelso
Jun 1, 1990·Parasitology Today·C BogdanW Solbach
Feb 1, 1993·Neurochemistry International·D A ChambersR L Perlman
Jan 1, 1991·Research in Immunology·R L Coffman, T R Mosmann
Jan 1, 1991·Research in Immunology·T F Gajewski, F W Fitch
Jan 1, 1991·Research in Immunology·M E WilliamsA K Abbas
Apr 1, 1989·Current Opinion in Immunology·G DelespesseC Heusser
Mar 26, 1998·International Journal for Parasitology·K A Taylor
Mar 21, 1998·International Journal for Parasitology·A W Taylor-Robinson
Nov 1, 1996·Journal of the Neurological Sciences·M R BongioanniB Bergamasco
Mar 1, 1991·Immunology Today·T R Mosmann, K W Moore
Mar 1, 1991·Immunology Today·N Schweitzer, R Anderson
Jul 22, 1998·Journal of Hepatology·R M HoffmannG R Pape
Aug 23, 2001·International Immunopharmacology·R C van der Veen
Jun 5, 2003·International Immunopharmacology·Kiyoshi Takatsu, Ai Kariyone
Apr 21, 1994·The New England Journal of Medicine·L G Lange, G F Schreiner
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Troye-BlombergP Perlmann
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S HsiehK M Murphy
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·F RomainG Marchal
Nov 3, 2010·The Journal of Biological Chemistry·Zhonghua YanRuma Banerjee
Dec 1, 1991·The Journal of Experimental Medicine·R A DaynesB A Araneo
Jun 1, 1993·The Journal of Experimental Medicine·M D ToddL H Glimcher
Apr 1, 1994·The Journal of Experimental Medicine·T Yoshimoto, W E Paul

❮ Previous
Next ❯

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