Regulation of T Helper Cell Fate by TCR Signal Strength.

Frontiers in Immunology
Nayan D Bhattacharyya, Carl G Feng

Abstract

T cells are critical in orchestrating protective immune responses to cancer and an array of pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting cells (APCs) and T cell receptors (TCRs) on T cells initiates T cell activation, division, and clonal expansion in secondary lymphoid organs. T cells must also integrate multiple T cell-intrinsic and extrinsic signals to acquire the effector functions essential for the defense against invading microbes. In the case of T helper cell differentiation, while innate cytokines have been demonstrated to shape effector CD4+ T lymphocyte function, the contribution of TCR signaling strength to T helper cell differentiation is less understood. In this review, we summarize the signaling cascades regulated by the strength of TCR stimulation. Various mechanisms in which TCR signal strength controls T helper cell expansion and differentiation are also discussed.

References

Mar 1, 1974·The Journal of Experimental Medicine·P H LagrangeT E Miller
Nov 1, 1995·The Journal of Experimental Medicine·S ConstantK Bottomly
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·T JayaramanA R Marks
Apr 1, 1995·The Journal of Experimental Medicine·C PfeifferK Bottomly
Jan 1, 1996·Annual Review of Immunology·J Sloan-Lancaster, P M Allen
May 19, 1997·The Journal of Experimental Medicine·C WülfingM M Davis
Jun 11, 1998·The Journal of Biological Chemistry·S HashemolhosseiniS Ferrari
Jun 30, 1998·International Immunology·M YamashitaT Nakayama
Jun 9, 1999·Current Biology : CB·L P KaneA Weiss
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·W ReesJ Kappler
Mar 23, 2001·Nature Immunology·A V Gett, P D Hodgkin
Oct 18, 2000·The Journal of Experimental Medicine·R M KedlP Marrack
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y HaradaR Abe
Jan 12, 2002·The Journal of Biological Chemistry·Bin ZhouH Scott Baldwin
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leonard J ApplemanVassiliki A Boussiotis
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wataru IseShuichi Kaminogawa
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer L BrogdonKim Bottomly
May 4, 2002·Nature Cell Biology·Eitan Shaulian, Michael Karin
Jul 18, 2002·Immunity·Kenneth A FrauwirthCraig B Thompson
Oct 9, 2002·The Journal of Experimental Medicine·Yosef RefaeliAbul K Abbas
Oct 25, 2002·Nature·Darrell J IrvineMark M Davis
Oct 29, 2002·Trends in Immunology·Rosemary J Boyton, Daniel M Altmann

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Citations

Feb 20, 2021·Frontiers in Immunology·Matthew ClarkRoland M Tisch
Mar 9, 2021·Frontiers in Immunology·Qi KeRoland M Tisch
Apr 3, 2021·Cellular & Molecular Immunology·Georgios SogkasReinhold Ernst Schmidt
Oct 16, 2020·Immunological Reviews·Michele K Anderson, Johanna S Selvaratnam
Mar 30, 2021·Frontiers in Immunology·Jongdae LeeJose M González-Navajas
May 30, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nayan D BhattacharyyaCarl G Feng
Jun 20, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tina ArkeeGail A Bishop
Oct 16, 2021·Science Immunology·Carlos A CastellanosJeoung-Sook Shin

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BETA
nuclear translocation
transgenic

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