PMID: 9556128Apr 29, 1998Paper

Regulation of tenascin-C expression in bone cells by transforming growth factor-beta

Bone
E J MackieL I Murphy

Abstract

Transforming growth factor-beta (TGF-beta) stimulates new bone formation when administered locally in vivo. The extracellular matrix protein tenascin-C, which is secreted by osteoblasts but absent from mineralized bone matrix, supports differentiation of cultured osteoblast-like cells. The current study was undertaken to determine whether expression patterns of tenascin-C in TGF-beta-treated bone cells are in agreement with a role for this protein as a mediator of TGF-beta-stimulated new bone formation. Expression of tenascin-C was investigated by immunohistochemistry in calvarial bones of mice to which TGF-beta had been locally administered. Three days after initiation of daily TGF-beta treatment, strong staining for tenascin-C was seen in regions where periosteal osteoprogenitor cells were undergoing proliferation in response to TGF-beta; by comparison, staining of periosteal surfaces of control bones was weak and discontinuous. Seven days after initiation of a course of five daily injections of TGF-beta, tenascin-C staining was still enhanced in treated bones. The ability of TGF-beta to regulate expression of tenascin-C in osteoblast-like cells in vitro was investigated using an osteosarcoma-derived cell line (ROS 17/2.8). T...Continue Reading

References

Sep 1, 1992·Calcified Tissue International·L MasiF Beghè
Oct 1, 1992·Genes & Development·Y SagaS Aizawa
Aug 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J PfeilschifterR Ziegler
Dec 1, 1988·The Journal of Cell Biology·E J MackieD Liverani
Jan 1, 1988·Archives of Oral Biology·I ThesleffR Chiquet-Ehrismann
Jun 1, 1989·Endocrinology·M Noda, J J Camilliere
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S M SeyedinK A Piez
Nov 1, 1980·Endocrinology·R J MajeskaG A Rodan
Oct 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Chiquet-EhrismannS Schenk
Jan 10, 1994·FEBS Letters·A LinnalaI Virtanen
Feb 15, 1994·Journal of Neuroscience Research·U Dörries, M Schachner
Jan 11, 1993·Nucleic Acids Research·P Sriramarao, M A Bourdon
Apr 5, 1996·Biochemical and Biophysical Research Communications·F FukamauchiM Kusakabe
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·E ForsbergR Fässler
Jan 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M WebbE J Mackie
Dec 31, 1997·Molecular Biology of the Cell·D FischerJ C Adams
Dec 31, 1997·Science·F S CollinsA Charkravarti

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Citations

Apr 5, 2000·Progress in Neurobiology·P Pesheva, R Probstmeier
Jan 5, 2002·Journal of the American College of Cardiology·Jari SattaYlermi Soini
Sep 9, 2008·Tissue Engineering. Part a·Sara H McBrideMelissa L Knothe Tate
Aug 25, 2011·Journal of Neurosurgical Anesthesiology·Hidenori SuzukiWaro Taki
Apr 14, 2006·Cells, Tissues, Organs·Lynne A Opperman, Joseph T Rawlins
Jul 16, 2008·The International Journal of Biochemistry & Cell Biology·Melissa L Knothe TateUlf R Knothe
Mar 11, 2016·Drug Discoveries & Therapeutics·Chengzhi LiJinxiang Han
Jul 8, 2003·The Journal of Pathology·Ruth Chiquet-Ehrismann, Matthias Chiquet
Dec 8, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ioannis ChristodoulouJulia M Polak
Sep 29, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Falk WehrhanStefan Schultze-Mosgau
Mar 30, 2006·Experimental Hematology·Masanori SekiTakeshi Sasaki
Apr 19, 2018·Tissue Engineering. Part a·Marta BaroncelliJohannes P T M van Leeuwen
Jul 19, 2017·Antioxidants & Redox Signaling·David Labrousse-AriasMaría J Calzada
Jul 9, 2010·The Journal of Craniofacial Surgery·Jackie LeeMichael T Longaker
Sep 28, 2002·Journal of Dental Research·K KohamaM Ohishi

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