Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases.

Cell Death Discovery
Weihuang ZhangHuafeng Liu

Abstract

The transcription factor EB (TFEB) regulates the expression of target genes bearing the Coordinated Lysosomal Expression and Regulation (CLEAR) motif, thereby modulating autophagy and lysosomal biogenesis. Furthermore, TFEB can bind to the promoter of autophagy-associated genes and induce the formation of autophagosomes, autophagosome-lysosome fusion, and lysosomal cargo degradation. An increasing number of studies have shown that TFEB stimulates the intracellular clearance of pathogenic factors by enhancing autophagy and lysosomal function in multiple kidney diseases, such as cystinosis, acute kidney injury, and diabetic nephropathy. Taken together, this highlights the importance of developing novel therapeutic strategies against kidney diseases based on TFEB regulation. In this review, we present an overview of the current data on TFEB and its implication in kidney disease.

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Citations

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Methods Mentioned

BETA
environmental stresses
biopsies

Related Concepts

Autophagy
Diabetic Nephropathy
Genes
Kidney Diseases
Lysosomes
Promoter
Intracellular
Lysosome Organization
Protein Expression
Regulation of Biological Process

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