Regulation of the 75-kDa subunit of mitochondrial complex I by iron

The Journal of Biological Chemistry
E LinG A Freyer

Abstract

Iron homeostasis is tightly regulated, as cells work to conserve this essential but potentially toxic metal. The translation of many iron proteins is controlled by the binding of two cytoplasmic proteins, iron regulatory protein 1 and 2 (IRP1 and IRP2) to stem loop structures, known as iron-responsive elements (IREs), found in the untranslated regions of their mRNAs. In short, when iron is depleted, IRP1 or IRP2 bind IREs; this decreases the synthesis of proteins involved in iron storage and mitochondrial metabolism (e.g. ferritin and mitochondrial aconitase) and increases the synthesis of those involved in iron uptake (e.g. transferrin receptor). It is likely that more iron-containing proteins have IREs and that other IRPs may exist. One obvious place to search is in Complex I of the mitochondrial respiratory chain, which contains at least 6 iron-sulfur (Fe-S) subunits. Interestingly, in idiopathic Parkinson's disease, iron homeostasis is altered, and Complex I activity is diminished. These findings led us to investigate whether iron status affects the Fe-S subunits of Complex I. We found that the protein levels of the 75-kDa subunit of Complex I were modulated by levels of iron in the cell, whereas mRNA levels were minimally ...Continue Reading

References

Aug 1, 1992·Quarterly Reviews of Biophysics·J E Walker
Jul 17, 1992·Biochimica Et Biophysica Acta·J M CooperA H Schapira
May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A PietrangeloG Cairo
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D M KoellerJ B Harford
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M W HentzeR D Klausner
Nov 11, 1987·Nucleic Acids Research·J F MilliganO C Uhlenbeck
Feb 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J W Langston, P Ballard
Jan 1, 1995·Gastroenterology·A PietrangeloG Cairo
Dec 1, 1994·Annals of Neurology·V M MannA H Schapira
May 1, 1993·Biochemical Society Transactions·A H SchapiraJ M Cooper
Jan 1, 1993·Molecular Biology of the Cell·R D Klausner, T A Rouault
Feb 1, 1993·Biochemical Society Transactions·S J PilkingtonJ E Walker
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·N K GrayM W Hentze
Aug 1, 1996·Current Opinion in Neurology·A H Schapira
Dec 1, 1996·Neurology·P Jenner, C W Olanow
Jun 19, 1998·Biochimica Et Biophysica Acta·A H Schapira
Sep 28, 1998·Annals of Neurology·P Jenner, C W Olanow
Nov 22, 2000·The Biochemical Journal·G Cairo, A Pietrangelo

❮ Previous
Next ❯

Citations

Feb 14, 2002·Archives of Biochemistry and Biophysics·Hani AtamnaBruce N Ames
Sep 17, 2002·Molecular Aspects of Medicine·Brian A C Ackrell
Jun 12, 2002·Free Radical Biology & Medicine·Gaetano CairoGiorgio Minotti
Aug 27, 2005·Mitochondrion·S M S BuddeJ A M Smeitink
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Toshihiko Ubuka
Oct 27, 2011·Accounts of Chemical Research·Dixie J Goss, Elizabeth C Theil
Jun 18, 2002·Journal of Neurochemistry·Benoît ChénaisJean-Claude Drapier
May 22, 2007·RNA·Paul Piccinelli, Tore Samuelsson
Jun 8, 2007·FEBS Letters·Eduardo Solano-GonzálezRossana Arroyo
Dec 26, 2015·Biomolecules·Elisa E Figueroa-AnguloRossana Arroyo
Jun 23, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·J C Torres-Romero, R Arroyo
Aug 5, 2008·Neurobiology of Disease·Shannon L Rhodes, Beate Ritz
Aug 20, 2010·Journal of Neuroscience Research·Amanda M SnyderJames R Connor
Jul 3, 2004·Ageing Research Reviews·Deepinder Kaur, Julie Andersen
Oct 15, 2013·Neurobiology of Disease·Shannon L RhodesBeate Ritz
Jun 4, 2004·American Journal of Physiology. Cell Physiology·William E CroweJohn M Russell
Nov 1, 2018·Journal of Neurochemistry·Xiao Tian HuangHai Yan Zhang
Jan 14, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Gregory J ConnellChristian X Haastruthers
May 3, 2002·Blood·Frank M Torti, Suzy V Torti
Jul 3, 2007·The Journal of Biological Chemistry·Wei WangFrank M Torti
Oct 10, 2009·Journal of Neuropathology and Experimental Neurology·Amanda M SnyderJames R Connor
Feb 24, 2005·Molecular and Cellular Biochemistry·Zvezdana Popovic, Douglas M Templeton
Oct 5, 2006·Experimental Biology and Medicine·Haobin Chen, Max Costa

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.