Regulation of the acid-labile subunit in sustained endotoxemia

American Journal of Physiology. Endocrinology and Metabolism
Sung-Eun KongP Delhanty

Abstract

The effect of sustained endotoxemia on expression of the acid-labile subunit (ALS) in relation to hepatic markers of altered GH and insulin sensitivity was examined. Juvenile rats were injected with endotoxin twice daily for 48 h, causing reduced food intake and attenuated growth. In pair-fed controls, food restriction caused marked suppression of ALS gene expression and circulating levels within 12 h, and endotoxemia augmented this effect. This acute effect of endotoxin corresponded temporally with transient induction of suppressor of cytokine signaling (SOCS)-3, cytokine-inducible SH2-containing protein (CIS), phosphoenolpyruvate carboxykinase (PEPCK), and insulin-like growth factor-binding protein (IGFBP)-1 and suppression of GH receptor (GHR). During the subsequent 36 h of sustained endotoxin treatment, expression of ALS recovered to, and then rose above, that of their pair-fed controls. This effect was paralleled by other ternary complex components. The inductive effect of sustained endotoxemia relative to pair-fed controls could not be explained by differences in expression of GHR, SOCS-3, or CIS but coincided with normalized PEPCK and IGFBP-1 levels, suggesting better hepatic insulin sensitivity in these animals. These d...Continue Reading

References

Sep 29, 1978·Biochemical and Biophysical Research Communications·R C Baxter, J R Turtle
Aug 1, 1992·The Journal of Endocrinology·B A CrawfordR C Baxter
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R C Baxter, J L Martin
Apr 1, 1995·The American Journal of Physiology·M M WojnarC H Lang
Jul 1, 1995·The American Journal of Physiology·J FanC H Lang
Oct 31, 1998·The Journal of Endocrinology·L SotoA López-Calderón
Mar 10, 1999·The American Journal of Physiology·D DefalqueJ P Thissen
Mar 10, 1999·The American Journal of Physiology·C H LangR A Frost
Aug 13, 1999·The American Journal of Physiology·J FrystykR C Baxter
Dec 10, 1999·The Journal of Biological Chemistry·P A Ram, D J Waxman
Mar 11, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·E M ZimmermannP K Lund
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A BarrecaJ P Thissen
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·E SvanbergT C Vary
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Robert C BaxterSue M Firth
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·R C Baxter
Feb 28, 2002·Endocrinology·Váronique BeauloyeJean-Paul Thissen

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Citations

Jul 18, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·R NovosyadlyyJ-G Scharf
Mar 6, 2007·Endocrinology and Metabolism Clinics of North America·David R Clemmons
Nov 28, 2006·Endocrinology and Metabolism Clinics of North America·Dieter Mesotten, Greet Van den Berghe

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