Regulation of the activins-follistatins-inhibins axis by energy status: Impact on reproductive function.

Metabolism: Clinical and Experimental
Nikolaos PerakakisChristos S Mantzoros

Abstract

We have previously demonstrated that the adipose tissue derived hormone leptin controls reproductive function by regulating the hypothalamic-pituitary-gonadal axis in response to energy deficiency. Here, we evaluate the activins-follistatins-inhibins (AFI) axis during acute (short-term fasting in healthy people) and chronic energy deficiency (women with hypothalamic amenorrhea due to strenuous exercise [HA]) and investigate their relation to leptin and reproductive function in healthy subjects and subjects with HA. The AFI axis was investigated in: a) A double-blinded study in healthy subjects having three randomly assigned admissions, each time for four days: in the isocaloric fed state, complete fasting with placebo treatment, complete fasting with leptin replacement, b) A case-control study comparing women with HA vs healthy controls, c) An open-label interventional study investigating leptin treatment in women with HA over a period of up to three months, d) A randomized interventional trial investigating leptin treatment vs placebo in women with HA for nine months. The circulating levels of activin A, activin B, follistatin and follistatin-like 3 change robustly in response to acute and chronic energy deficiency. Leptin rep...Continue Reading

Citations

Aug 8, 2018·The Journal of Clinical Endocrinology and Metabolism·Nikolaos PerakakisChristos S Mantzoros
Nov 6, 2018·Diabetes, Obesity & Metabolism·Nikolaos PerakakisChristos S Mantzoros
Dec 20, 2018·The Journal of Pharmacology and Experimental Therapeutics·Roselyne CastonguayRavi Kumar
Feb 7, 2020·Diabetes/metabolism Research and Reviews·Nikolaos PerakakisChristos S Mantzoros
Nov 7, 2019·The Journal of Clinical Endocrinology and Metabolism·Stergios A PolyzosChristos S Mantzoros
Jun 20, 2020·Hormones : International Journal of Endocrinology and Metabolism·Konstantina DiplaAnthony C Hackney
Sep 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Aesha ShahRichard S Legro
Oct 13, 2020·Metabolism: Clinical and Experimental·Eirini BouzoniChristos S Mantzoros

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Sharon ChouChristos S Mantzoros
The New England Journal of Medicine
Corrine K WeltChristos S Mantzoros
Proceedings of the National Academy of Sciences of the United States of America
Giuseppe MatareseChristos S Mantzoros
The New England Journal of Medicine
Antonio LaMarca, Annibale Volpe
© 2022 Meta ULC. All rights reserved