PMID: 7393346May 1, 1980

Regulation of the adenylate cyclase system by catecholamines in the rat prostate

Naunyn-Schmiedeberg's Archives of Pharmacology
S ShimaM Asakura


Tolerance to catecholamines in the beta-adrenergic and dopaminergic receptor-adenylate cyclase system from the rat prostatic membrane has been studied. Preincubation of the tissue with isoproterenol produced not only a decrease in beta-adrenergic receptors and its sensitive adenylate cyclase activity, but also a reduction in dopaminergic response. Similarly, exposure to dopamine resulted in a decline both of isoproterenol- and dopamine-stimulated adenylate cyclase activity. A beta adrenergic antagonist, propranolol, exclusively blocked desensitization in the beta-adrenergic and dopaminergic adenylate cyclase system caused by isoproterenol, while dopamine-induced refractoriness was prevented by a dopaminergic antagonist, haloperidol. These results suggest that desensitization of the beta-adrenergic and dopaminergic adenylate cyclase system begins on receptor-occupation by its specific agonist.


Mar 22, 1979·Biochimica Et Biophysica Acta·P Nambi, G I Drummond
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C MukherjeeR J Lefkowitz
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J W KebabianJ Axelrod
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Jan 1, 1971·Biochimica Et Biophysica Acta·S LiaoJ L Tymoczko
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·T Deguchi, J Axelrod
Mar 20, 1980·Biochimica Et Biophysica Acta·S ShimaM Asakura

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Tissue Membrane
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