Regulation of the anterior-like cell state by ammonia in Dictyostelium discoideum

Developmental Genetics
I N FeitH B Suthers

Abstract

Ammonia appears to be an important regulatory signal for several aspects of the Dictyostelium life cycle. The postulated role of ammonia in the determination of the prespore pathway in cells of the slug stage has led us to examine the effect of ammonia on the prestalk/prespore ratio of migrating slugs. In the presence of 10(-3) M ammonium chloride, the volume of the prestalk region decreases by 40.8%. The kinetics of the process make it unlikely that this is due to a shift in the differentiation pathway. A test of the hypothesis that the decrease in volume of the prestalk region is due to the conversion of prestalk cells to anterior-like cells shows that the percent of anterior-like cells in the posterior region increases by the amount predicted by the hypothesis. This suggests that ammonia may be the molecular signal, produced by the tip, that prevents anterior-like cells from chemotactically migrating to the tip and thereby becoming anterior cells. The effect of enzymatic removal of ammonia from vitally stained migrating slugs is the appearance of a series of dark stripes beginning at the posterior end and progressing forward. We interpret this as a result of progressive removal of anterior-like cells from tip dominance and e...Continue Reading

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Citations

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E K Rooney, J D Gross
Sep 29, 2011·Development, Growth & Differentiation·Kerry A FlegelCynthia K Damer
Nov 3, 2009·Evolution & Development·Nameeta MujumdarVidyanand Nanjundiah
Jun 29, 1993·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J G WilliamsM Veron
Jun 15, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Pauline Schaap
Oct 1, 1992·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·John Sternfeld
May 20, 2003·Evolution & Development·John Tyler Bonner
Sep 1, 1994·Microbiological Reviews·J D Gross
Dec 23, 2003·Differentiation; Research in Biological Diversity·Susan C FollstaedtCharles K Singleton
Oct 1, 1991·Current Opinion in Genetics & Development·J G Williams

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