PMID: 6778511Jan 1, 1980Paper

Regulation of the biosynthesis of branched aminoacyl tRNA synthetases in Bacillus cereus T

Biochimie
J Raimond

Abstract

The regulation of the biosynthesis of isoleucyl-, valyl-, and leucyl-tRNA synthetases was studied with an isoleucine-valine requiring mutant of Bacillus cereus T. It was shown that valyl-tRNA synthetase regulation is under multivalent control involving both valine and isoleucine. The isoleucyl- and leucyl-tRNA synthetases are repressed by the respective cognate amino acid. When two amino acids were removed from the culture medium, derepression of the two corresponding aminoacyl tRNA synthetases was expected, but only one appears. With a threonine deaminase constitutive mutant, it was demonstrated that the derepression mecanism of the synthetase was correlated with the intracellular level of the ilv A gene product. These results are in good agreement with the model proposed by several authors. In this model, threonine deaminase, or some form of this enzyme, is involved in a positive control of the regulation of the branched-chain aminoacyltransfer ribonucleic acid synthetases.

References

Apr 15, 1976·Journal of Molecular Biology·M LevinthalL S Williams
Oct 18, 1976·Molecular & General Genetics : MGG·J M SmithH E Umbarger
Apr 1, 1972·Biochemical Genetics·J M Blatt, H E Umbarger
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D H Calhoun, G W Hatfield
Nov 21, 1973·Nature: New Biology·M LevinthalH E Umbarger

Related Concepts

Amino Acyl-tRNA Synthetases
Bacillus cereus
Alloisoleucine
Isoleucine-tRNA Ligase
Leucine
Leucine-tRNA Ligase
Threonine Dehydratase
Valine
Valine-tRNA Ligase

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