PMID: 6778511Jan 1, 1980Paper

Regulation of the biosynthesis of branched aminoacyl tRNA synthetases in Bacillus cereus T

J Raimond


The regulation of the biosynthesis of isoleucyl-, valyl-, and leucyl-tRNA synthetases was studied with an isoleucine-valine requiring mutant of Bacillus cereus T. It was shown that valyl-tRNA synthetase regulation is under multivalent control involving both valine and isoleucine. The isoleucyl- and leucyl-tRNA synthetases are repressed by the respective cognate amino acid. When two amino acids were removed from the culture medium, derepression of the two corresponding aminoacyl tRNA synthetases was expected, but only one appears. With a threonine deaminase constitutive mutant, it was demonstrated that the derepression mecanism of the synthetase was correlated with the intracellular level of the ilv A gene product. These results are in good agreement with the model proposed by several authors. In this model, threonine deaminase, or some form of this enzyme, is involved in a positive control of the regulation of the branched-chain aminoacyltransfer ribonucleic acid synthetases.


Apr 15, 1976·Journal of Molecular Biology·M LevinthalL S Williams
Oct 18, 1976·Molecular & General Genetics : MGG·J M SmithH E Umbarger
Apr 1, 1972·Biochemical Genetics·J M Blatt, H E Umbarger
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D H Calhoun, G W Hatfield
Nov 21, 1973·Nature: New Biology·M LevinthalH E Umbarger

Related Concepts

Amino Acyl-tRNA Synthetases
Bacillus cereus
Isoleucine-tRNA Ligase
Leucine-tRNA Ligase
Threonine Dehydratase
Valine-tRNA Ligase

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.