Regulation of the chemotaxis histidine kinase CheA: A structural perspective

Biochimica Et Biophysica Acta. Biomembranes
Alise R MuokBrian R Crane

Abstract

Bacteria sense and respond to their environment through a highly conserved assembly of transmembrane chemoreceptors (MCPs), the histidine kinase CheA, and the coupling protein CheW, hereafter termed "the chemosensory array". In recent years, great strides have been made in understanding the architecture of the chemosensory array and how this assembly engenders sensitive and cooperative responses. Nonetheless, a central outstanding question surrounds how receptors modulate the activity of the CheA kinase, the enzymatic output of the sensory system. With a focus on recent advances, we summarize the current understanding of array structure and function to comment on the molecular mechanism by which CheA, receptors and CheW generate the high sensitivity, gain and dynamic range emblematic of bacterial chemotaxis. The complexity of the chemosensory arrays has motivated investigation with many different approaches. In particular, structural methods, genetics, cellular activity assays, nanodisc technology and cryo-electron tomography have provided advances that bridge length scales and connect molecular mechanism to cellular function. Given the high degree of component integration in the chemosensory arrays, we ultimately aim to unders...Continue Reading

Citations

Apr 30, 2020·Molecular Microbiology·Davi R OrtegaAriane Briegel
Apr 29, 2020·Journal of Bacteriology·Se-Young JunGerald L Hazelbauer
Feb 6, 2020·Frontiers in Microbiology·Alejandra AlvaradoChristine Josenhans
Nov 12, 2020·Science Signaling·Alise R MuokBrian R Crane
Apr 4, 2021·Biomolecules·Alister BurtIrina Gutsche
Jun 3, 2021·International Journal of Molecular Sciences·Ivan GushchinValentin Gordeliy
Sep 9, 2021·Biochemical Society Transactions·Zhuan Qin, Peijun Zhang

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