PMID: 2503829Aug 1, 1989Paper

Regulation of the complex pattern of sevenless expression in the developing Drosophila eye

Proceedings of the National Academy of Sciences of the United States of America
D D BowtellG M Rubin

Abstract

The sevenless gene encodes a cell surface receptor that has protein-tyrosine kinase activity and is expressed in a highly specific and complex pattern in the developing Drosophila eye. We have coupled the sevenless promoter to the reporter gene lacZ and have examined the pattern of beta-galactosidase expression in the developing eyes of transgenic larvae. Our results indicate that the dynamic pattern of sevenless protein expression is regulated transcriptionally. Promoter sequences located 5' of the coding region are insufficient for the wild-type level of gene expression but appear to be able to confer the correct pattern of expression. In contrast, enhancer sequences within the body of the gene can confer both the correct pattern and a normal level of expression on either the sevenless promoter or heterologous promoters. Thus the complex pattern of sevenless expression is redundantly encoded within proximal promoter sequences and enhancer elements internal to the gene but relies on these enhancer sequences for correct quantitative expression.

References

Jul 1, 1979·Developmental Biology·P A Lawrence, S M Green
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Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C J O'Kane, W J Gehring
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Citations

Jul 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J W SentryK Kaiser
Mar 1, 1997·Invertebrate Neuroscience : in·T ThomasN S Atkinson
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M A SimonG M Rubin
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W M MichaelG M Rubin
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·U Heberlein, G M Rubin
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D D BowtellG M Rubin
Apr 11, 2000·Molecular and Cellular Biology·Y TakatsuN Ueno
Sep 3, 2011·PLoS Biology·Andrew TomlinsonGary Struhl
Aug 1, 1990·Analytical Biochemistry·J Alam, J L Cook
Dec 17, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Justin P Kumar
Mar 18, 2016·Genetics·Amanda J BlickJack R Bateman

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