Regulation of the DNA binding of p53 by its interaction with protein kinase CK2

FEBS Letters
A ProwaldMathias Montenarh

Abstract

Some of the numerous functions of the growth suppressor protein p53 are regulated by its interaction with viral and cellular proteins. C-terminal sequences of p53 are implicated in binding to the regulatory beta-subunit of protein kinase CK2. Using a p53-specific DNA binding element we found that the beta-subunit of CK2 inhibited the DNA binding of p53 whereas the alpha-subunit had no influence. The CK2 holoenzyme consisting of two alpha- and two beta-subunits led to a supershift in DNA binding of p53 similar to the p53-specific monoclonal antibody PAb421 as well as the C-terminus of p53. Thus, our results showed an individual role of the free beta-subunit of CK2 on the DNA binding activity of p53.

References

Apr 1, 1992·Nature Genetics·W S el-DeiryB Vogelstein
Nov 27, 1992·Cell·T R HuppD P Lane
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J BaudierJ J Lawrence
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E SetoT Shenk
Jan 1, 1992·The Journal of Cell Biology·W KrekE A Nigg
Oct 11, 1991·Nucleic Acids Research·O S FoordV Rotter
May 23, 1991·European Journal of Biochemistry·N GrankowskiO G Issinger
Jun 21, 1991·Science·S E KernB Vogelstein
Dec 31, 1990·Biochemical and Biophysical Research Communications·O FilholE M Chambaz
Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·C PrivesU Hubscher
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·H Lu, A J Levine
Aug 30, 1994·Biochemical and Biophysical Research Communications·P JacksonA Braithwaite
Mar 1, 1994·European Journal of Biochemistry·B Lüscher, D W Litchfield
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y ShiC T Walsh
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·X Wu, A J Levine
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Jan 1, 1993·Pharmacology & Therapeutics·O G Issinger
Jul 1, 1993·Genes & Development·X WuA J Levine
Jul 11, 1993·Nucleic Acids Research·T R HuppD P Lane
Jan 1, 1996·Reviews of Physiology, Biochemistry and Pharmacology·C Götz, M Montenarh
Dec 18, 1995·FEBS Letters·P WagnerW Nastainczyk
Mar 1, 1996·Molecular and Cellular Biology·U M MollG Zambetti
Aug 2, 1996·Journal of Molecular Biology·T Soussi, P May

❮ Previous
Next ❯

Citations

Feb 17, 2001·Journal of Cellular Biochemistry·N SchusterM Montenarh
Oct 27, 2010·Cell and Tissue Research·Mathias Montenarh
Jul 2, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Steven O SimmonsRam Ramabhadran
Jun 10, 2010·BioFactors·Janeen H TrembleyKhalil Ahmed
May 29, 2002·Oncogene·Cunjie ZhangDavid W Litchfield
May 8, 2018·Cancers·Justina KasteriMoira Sauane
Jul 20, 2011·Molecular and Cellular Biochemistry·David W Meek, Miranda Cox
Jul 31, 2002·Biochemical and Biophysical Research Communications·Michael FaustMathias Montenarh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis