Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH.

The Journal of Biological Chemistry
Y ChenG N Gill

Abstract

Within the human ERBB-2 gene promoter, a 100-base pair region 5' to the TATA box enhances basal transcription 200-fold. Two palindromes present within this 100-base pair region are important for transcription. The palindrome binding protein was purified to homogeneity and found to be identical to RBPJkappa, the mammalian homolog of Drosophila Suppressor of Hairless (Su(H)). Recombinant RBPJkappa bound the ERBB-2 promoter with affinity comparable with that seen with well characterized RBPJkappa binding sites. RBPJkappa activated an ERBB-2 palindrome-containing promoter in 293 cells. Because in Drosophila Su(H) acts downstream of NOTCH and because NOTCH.Su(H)/RBPJkappa stimulates transcription from target promoters, NOTCH-IC, a constitutively active form of NOTCH, was tested for effects on the ERBB-2 palindrome. NOTCH-IC further increased RBPJkappa-mediated transcription on wild type but not mutant ERBB-2 palindrome. Thus, RBPJkappa can activate ERBB-2 transcription and serve as an anchor to mediate NOTCH function on the ERBB-2 gene.

References

Jan 1, 1991·Molecular and Cellular Biology·T C Suen, M C Hung
Apr 1, 1991·Molecular and Cellular Biology·D H Yan, M C Hung
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D YuM C Hung
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S IshiiT Yamamoto
Feb 1, 1985·Molecular and Cellular Biology·P A Norton, J M Coffin
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Y KokaiM I Greene
Aug 1, 1987·Molecular and Cellular Biology·C Chen, H Okayama
Feb 1, 1987·Molecular and Cellular Biology·J R de WetS Subramani
Sep 28, 1995·Nature·S JarriaultA Israel
Apr 14, 1995·Science·S Artavanis-TsakonasM E Fortini
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·J M BosherH C Hurst
Oct 21, 1994·Cell·M E Fortini, S Artavanis-Tsakonas
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·S R GrossmanE Kieff
Mar 25, 1994·Nucleic Acids Research·T TunM Kawaichi
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·F M Lu, S E Lux
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·R KopanJ S Nye
Nov 15, 1996·Science·Y Tanabe, T M Jessell

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Citations

Jul 12, 2002·Journal of Cellular Biochemistry·Denis G Bosc, Ralf Janknecht
Aug 31, 2000·Biochemical and Biophysical Research Communications·M M Maier, M Gessler
Sep 2, 2006·Journal of Mammary Gland Biology and Neoplasia·Wen Shi, Adrian L Harris
Jan 30, 2013·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Ming HanRong Jiang
Apr 29, 2011·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yoshinori ItoKiyohiko Hatake
Nov 5, 2013·Biochimica Et Biophysica Acta·Weiqiang ZhouShanchun Guo
Oct 1, 2013·Pharmacology & Therapeutics·Naoko TakebeSherry X Yang
Dec 21, 2006·Journal of the National Cancer Institute·Tiffany M PhillipsFrank Pajonk
Dec 6, 2005·Annals of Surgery·Peter BüchlerHelmut Friess
Sep 16, 2006·Journal of Virology·Sabine MaierBettina Kempkes
May 11, 2000·Molecular and Cellular Biology·S Jeffries, A J Capobianco
Aug 4, 2001·Molecular and Cellular Biology·T IsoY Hamamori
Jun 10, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Antonio PannutiLucio Miele
Mar 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ralf S SchmidEva S Anton
Dec 4, 2010·European Journal of Cell Biology·Ralf SchwanbeckUrsula Just
Nov 11, 1999·Oncogene·A DiévartP Jolicoeur
Jun 28, 2016·Parasitology Research·Lizandra G MagalhãesVanderlei Rodrigues
Jan 28, 2003·Journal of Cellular Physiology·Tatsuya IsoYasuo Hamamori
Sep 2, 2005·British Journal of Cancer·O HopferS Aebi
Oct 23, 2003·Nature Reviews. Cancer·Freddy Radtke, Kenneth Raj
Nov 5, 2014·Journal of Ovarian Research·Jolijn W GroenewegBo R Rueda
Apr 16, 2010·Expert Opinion on Therapeutic Targets·Elodie Ristorcelli, Dominique Lombardo
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Sanaz Tabarestani, Soudeh Ghafouri-Fard
Nov 1, 2014·Thoracic Cancer·Huajiao GuoJian Zhang
Feb 15, 2001·Oncogene·G K ScottC C Benz
Dec 14, 2001·The Journal of Biological Chemistry·Tatsuya IsoLarry Kedes
Oct 12, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·I A Voutsadakis
Oct 4, 2018·Viruses·Alessia VirzìJoachim Lupberger
Nov 18, 2005·Blood·Kevin G Leong, Aly Karsan
Dec 14, 2011·Asia-Pacific Journal of Clinical Oncology·Daoxin MaChunyan Ji
Sep 2, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Junming XuJun Liu
Aug 17, 2018·TheScientificWorldJournal·Emmanuel N KontomanolisZacharias N Fasoulakis
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alessandra MagnificoElda Tagliabue

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