Regulation of the Fas apoptotic cell death pathway by Abl.

The Journal of Biological Chemistry
A J McGahonD R Green

Abstract

Relatively little is known about oncogene involvement in the regulation of Fas-mediated apoptosis. Inhibition of Fas-induced cell death by the bcl-2 oncogene has been demonstrated to be only partial. In light of a growing body of evidence for the Abl kinase as a negative regulator of cell death, we sought to determine whether Abl expression could protect against Fas-mediated cell death. To address this question, we utilized two separate strategies. In the first, we expressed human Fas in K562, a chronic myelogenous leukemia cell line, which constitutively expresses bcr-abl and examined the effects of Fas ligation in these cells. Fas-positive K562 transformants (K562.Fas) were found to be protected against Fas-mediated cell death. However, down-regulation of Bcr-Abl protein levels in K562.Fas cells using antisense oligonucleotides targeted to bcr-abl mRNA rendered these cells highly susceptible to Fas-induced death. In the second approach we utilized a Fas-positive HL-60 cell line, which we transfected with a temperature-sensitive mutant of v-Abl. HL-60.v-Ablts transfectants were found to be protected from Fas-induced apoptosis at the permissive but not the restrictive temperature for the Abl kinase. Taken together, these observ...Continue Reading

References

Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E T KipreosJ Y Wang
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R K BestwickD Kabat
Nov 1, 1986·Molecular and Cellular Biology·B Mathey-PrevotD Baltimore
Aug 30, 1988·Biochemical and Biophysical Research Communications·L D TomeiC E Wenner
Oct 1, 1986·Journal of Cellular Physiology·I GuerreroD E Burstein
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Oct 1, 1994·The Journal of Experimental Medicine·M G CifoneR Testi
Mar 24, 1995·The Journal of Biological Chemistry·S J MartinD R Green
Jun 1, 1995·Molecular and Cellular Biology·L B Owen-SchaubE Kruzel
Jan 1, 1995·Methods in Cell Biology·A J McGahonD R Green
Jan 1, 1993·The Journal of Experimental Medicine·E RouvierP Golstein
Aug 1, 1994·The Journal of Experimental Medicine·A Haimovitz-FriedmanR N Kolesnick
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·W D JarvisS Grant
Mar 19, 1993·Science·L M ObeidY A Hannun

❮ Previous
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Citations

Jan 1, 1997·Journal of Cellular Biochemistry·B ZhivotovskyS Orrenius
Aug 5, 2000·International Journal of Cancer. Journal International Du Cancer·Y LiT Sato
Nov 1, 1996·Stem Cells·D J McConkey, S Orrenius
Dec 22, 1999·Biochemical and Biophysical Research Communications·M MaccarroneA Finazzi-Agro
Jun 2, 2000·Biochemical and Biophysical Research Communications·M MaccarroneA Finazzi-Agrò
Jan 1, 1996·Pathology Oncology Research : POR·Dean G Tang, Arthur T Porter
Sep 1, 2005·Apoptosis : an International Journal on Programmed Cell Death·H C A Drexler, M Euler
Aug 1, 1996·Trends in Microbiology·G Gillet, G Brun
Sep 28, 1999·Life Sciences·S B CatrinaV Mutt
Mar 19, 1999·Immunology Today·J O'ConnellF Shanahan
Apr 25, 2000·Human Immunology·Y MurayamaM Inoue-Murayama
Jan 13, 1998·Biochimica Et Biophysica Acta·A B RaitanoC L Sawyers
Jun 1, 1997·Journal of Pharmacological and Toxicological Methods·E BennerS S Joshi
Jun 14, 2001·British Journal of Haematology·S W MorrisM C Kinney
Apr 2, 1999·The European Journal of Neuroscience·M J Courtney, E T Coffey
Mar 21, 1998·The Journal of Experimental Medicine·H HebestreitH U Simon
Jan 15, 1997·The EMBO Journal·E K EvansS Kornbluth
Apr 28, 1999·Journal of Cardiovascular Pharmacology·H IwamotoM Matsuzaki
Oct 2, 2002·Shock·Colm PowerH Paul Redmond
Sep 26, 2007·Anti-cancer Drugs·Nastaran HeidariMassoud Mahmoudian
Apr 1, 2003·Molecular and Cellular Biology·Daniela BarilàRoberto Testi
Apr 17, 2001·Journal of Neurosurgery·M ZuritaI Zurita
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·J A HoughtonD M Tillman
Oct 31, 1996·Experientia·A SamaliT G Cotter
Jun 16, 2001·International Immunopharmacology·D Verthelyi
Jun 7, 2005·Expert Opinion on Therapeutic Targets·Shaoguang Li
Jul 5, 2005·Expert Opinion on Investigational Drugs·T BrunnerC Mueller
May 4, 2012·Immunology Letters·Anikó HanczGabriella Sármay
Mar 14, 2007·The International Journal of Biochemistry & Cell Biology·Shaoguang Li
Apr 25, 2000·Experimental Cell Research·D E Wood, E W Newcomb
Dec 12, 2002·Oncogene·Scott K ShoreE Premkumar Reddy

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