Regulation of the function of mammalian myosin and its conformational change.

Biochemical and Biophysical Research Communications
Mitsuo Ikebe

Abstract

It has been known that the phosphorylation of the regulatory light chain, residing at the head/rod junction of the molecule activates the motor activity of smooth muscle and non-muscle conventional myosin (myosin II), and triggers a large conformational change of the molecule from the inhibited folded conformation to the active extended conformation. Recent structural analysis has revealed the structural basis of the inhibition of the motor function of the two heads in the inhibited conformation. On the other hand, recent studies have revealed that a processive unconventional myosin, myosin V, also shows a large change in the conformation from the folded to an extended form and this explains the activation mechanism of myosin V motor activity. These findings suggest the presence of a common scenario for the regulation of motor protein functions.

References

Mar 1, 1977·European Journal of Biochemistry·A Sobieszek
Dec 1, 1978·Journal of Biochemistry·H SuzukiS Watanabe
Jul 12, 1976·Biochemical and Biophysical Research Communications·A GóreckaD J Hartshorne
Jan 1, 1991·Cell Motility and the Cytoskeleton·K M Trybus
Dec 14, 1970·Journal of Molecular Biology·J Kendrick-JonesA G Szent-Györgyi
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K M TrybusS Lowey
Jun 25, 1996·Biochemical and Biophysical Research Communications·S Komatsu, H Hosoya
Aug 23, 1996·The Journal of Biological Chemistry·M AmanoK Kaibuchi
Aug 23, 1996·The Journal of Biological Chemistry·J J OlneyC R Cremo
Aug 17, 1999·Nature·A D MehtaR E Cheney
Sep 17, 1999·The Journal of Biological Chemistry·K M TrybusY Freyzon
Nov 13, 1999·Nature Cell Biology·D L CoyJ Howard
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·E M De La CruzH L Sweeney
Dec 30, 1999·The Journal of Cell Biology·T WendtK A Taylor
Mar 21, 2000·Biochimica Et Biophysica Acta·B BarylkoJ P Albanesi
Apr 4, 2000·Physiological Reviews·A M GordonM Regnier
Jun 2, 2000·Biochemical and Biophysical Research Communications·T SakamotoT Ando
Jun 24, 2000·Nature·M L WalkerP J Knight
Aug 18, 2000·The Journal of Biological Chemistry·K HommaM Ikebe
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·D W Provance, J A Mercer
Sep 12, 2001·Trends in Biochemical Sciences·K J Verhey, T A Rapoport
Dec 12, 2001·Nature Cell Biology·Claudia VeigelJustin E Molloy
Jan 24, 2002·Nature·Hiroto TanakaMitsuo Ikebe
Mar 12, 2002·Nature Cell Biology·Xufeng S WuJohn A Hammer
May 29, 2002·The Biochemical Journal·Andrea MurányiDavid J Hartshorne
Aug 9, 2003·The Journal of Biological Chemistry·Sitong ShengZhifeng Shao

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Citations

Oct 24, 2008·Nature Reviews. Molecular Cell Biology·Rong Li, Gregg G Gundersen
Jun 15, 2011·Nature Structural & Molecular Biology·Nobuhisa UmekiMitsuo Ikebe
May 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Nobuhisa UmekiMitsuo Ikebe
Mar 23, 2012·The Journal of Biological Chemistry·Zekuan LuXiang-dong Li
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Sabina Tahirovic, Frank Bradke
Jun 18, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Arun ChaudhuryRaj K Goyal
Mar 11, 2011·PLoS Computational Biology·Dana Bar-OnUri Ashery
Aug 13, 2013·Cellular and Molecular Life Sciences : CMLS·Rocío Aguilar-CuencaMiguel Vicente-Manzanares
May 5, 2010·The Journal of Cell Biology·Alexander HeuckDierk Niessing
May 25, 2010·Leukemia Research·Jbireal M Ali JbirealFrank Entschladen
Dec 15, 2012·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takayuki KibokuMasayuki Takahashi
May 11, 2011·Developmental Neurobiology·Guo-Ying Yang, Zhen-Ge Luo
Jul 5, 2011·Biophysical Journal·Yujie Sun, Yale E Goldman
Feb 3, 2018·Cardiovascular Research·Rhian M TouyzAugusto C Montezano
Aug 21, 2015·Nature Communications·Sehyun KimBrian David Dynlacht
Jun 9, 2019·The Journal of Biological Chemistry·Qing-Juan CaoXiang-Dong Li
Jul 25, 2017·Cold Spring Harbor Protocols·Daniel P Mulvihill
Jan 23, 2016·Oncotarget·Alba Juanes-GarcíaMiguel Vicente-Manzanares
Feb 26, 2016·The Journal of Biological Chemistry·Lin-Lin YaoXiang-dong Li
Jun 8, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bing ChenKaizhi Lu
Jan 18, 2013·American Journal of Physiology. Cell Physiology·Trent ButlerEng-Cheng Chan
Jul 22, 2017·Cellular and Molecular Life Sciences : CMLS·Ning ZhangXiang-Dong Li
Nov 2, 2016·The Journal of Cell Biology·Zenghui Xue, Anna Marie Sokac
Feb 20, 2021·The Journal of General Physiology·Lu WangChun Y Seow

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