Regulation of the glycosylated beta-lactoglobulin homolog, glycodelin [placental protein 14:(PP14)] in the baboon (Papio anubis) uterus

The Journal of Clinical Endocrinology and Metabolism
H M HausermannA T Fazleabas

Abstract

In vitro studies indicate that glycodelin (PP14) synthesis by the human endometrium increases dramatically at the time of implantation and early pregnancy. It has been postulated that this protein may have an immunosuppressive function. Due to the limitations associated with in vivo studies in the human, this study was undertaken to study the regulation of the baboon glycodelin homolog in vivo during the menstrual cycle and early pregnancy. In nonpregnant baboons, between days 10-12 postovulation (n = 3) the mid and apical regions of the glandular epithelium showed a distinct punctate staining pattern, which increased between days 12-18 of pregnancy (n = 3). Between days 25-60 of pregnancy, staining intensity in the glandular epithelium decreased. The decrease was more apparent at the implantation site compared with the nonimplantation site. The immunostaining correlated with the synthesis of radiolabeled baboon glycodelin in explant culture. Northern blot analysis demonstrated two messenger RNA (mRNA) transcripts [1.0 and 1.7 kilobases (kb)] in the baboon uterus compared with a single 1.0-kb transcript in the human, and mRNA expression was consistent with protein localization and synthesis. The protein and mRNA expression was ...Continue Reading

Citations

Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·A T FazleabasJ B Miller
Jul 9, 2004·Reproductive Biology and Endocrinology : RB&E·Paula CameoAsgerally T Fazleabas
Nov 23, 2006·Reproductive Biology and Endocrinology : RB&E·Julie M Hastings, Asgerally T Fazleabas
Apr 28, 2009·Genome Biology·Danielle G LemayMonique Rijnkels

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