Regulation of the H+/e- stoichiometry of cytochrome c oxidase from bovine heart by intramitochondrial ATP/ADP ratios

FEBS Letters
V Frank, B Kadenbach

Abstract

This paper describes the effect of intramitochondrial ATP/ADP ratios on the H+/e- stoichiometry of reconstituted cytochrome c oxidase (COX) from bovine heart. At 100% intraliposomal ATP the H+/e- stoichiometry of the reconstituted enzyme is decreased to half of the value measured below 98% intraliposomal ATP (above 2% ADP), while it remains constant up to 100% ADP. The decrease is obtained with different COX preparations, independent of the absolute value of the H+/e- stoichiometry. Decrease of H+/e- stoichiometry is prevented by preincubation of the enzyme with a tissue-specific monoclonal antibody to subunit VIa-H (heart type). Tissue-specific regulation of the efficiency of energy transduction in COX of muscle mitochondria could have a physiological function in maintaining the body temperature at rest or sleep, i.e. at low ATP expenditure.

References

Nov 15, 1981·The Biochemical Journal·W D SchwenkeH Sies
May 24, 1995·Biochimica Et Biophysica Acta·B KadenbachS Possekel
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G AnthonyB Kadenbach
Dec 5, 1995·Biochemical and Biophysical Research Communications·T RiegerB Kadenbach

❮ Previous
Next ❯

Citations

May 22, 2001·Archives of Biochemistry and Biophysics·L Gille, H Nohl
Dec 22, 1999·Biochemical and Biophysical Research Communications·Y KagawaH Endo
May 11, 2011·Journal of Bioenergetics and Biomembranes·Sergio Guerrero-CastilloSalvador Uribe-Carvajal
Sep 27, 2000·Biochimica Et Biophysica Acta·M HüttemannB Kadenbach
Aug 12, 2003·Gene·Maik HüttemannLawrence I Grossman
Oct 18, 2000·Free Radical Biology & Medicine·B KadenbachE Bender
Aug 1, 1997·Current Opinion in Structural Biology·S Yoshikawa
Dec 12, 2001·European Journal of Biochemistry·I Lee, B Kadenbach
Aug 3, 1999·European Journal of Biochemistry·B BeauvoitM Rigoulet
Jun 11, 2008·Molecular & Cellular Proteomics : MCP·Stefan HellingBernhard Kadenbach
Sep 22, 2007·Critical Care Medicine·Xavier M Leverve
Aug 15, 1997·European Journal of Biochemistry·S ArnoldB Kadenbach
Nov 18, 1997·European Journal of Biochemistry·S Arnold, B Kadenbach
Apr 5, 2003·Applied and Environmental Microbiology·Qusheng Jin, Craig M Bethke
Nov 5, 1997·Biological Chemistry·J NapiwotzkiB Kadenbach
Jul 28, 2004·Gene·Sakkapol Ongwijitwat, Margaret T T Wong-Riley
Jan 6, 2001·Redox Report : Communications in Free Radical Research·L A Videla
Sep 20, 2011·Biochimica Et Biophysica Acta·Amandine MaréchalPeter R Rich
Feb 2, 2008·Biochimica Et Biophysica Acta·Maik HüttemannJeffrey W Doan
May 30, 2006·Biochimica Et Biophysica Acta·Sergio PapaMarco Di Paola
May 30, 1998·Biochimica Et Biophysica Acta·H Rottenberg
May 5, 2009·Biochimica Et Biophysica Acta·Bernhard KadenbachSebastian Vogt
Aug 4, 2016·American Journal of Physiology. Cell Physiology·Tomas A SchifferFilip J Larsen
Apr 24, 1999·FEBS Letters·B Kadenbach, S Arnold
Apr 24, 2012·Proteomics·Stefan HellingKatrin Marcus
Dec 14, 2007·The Journal of Biological Chemistry·Shilpa S DharMargaret T T Wong-Riley
Oct 2, 2001·The Journal of Biological Chemistry·V NogueiraX M Leverve
Dec 8, 2005·Biotechnology and Bioengineering·Andy Rakestraw, K Dane Wittrup
Jun 9, 2017·Oxidative Medicine and Cellular Longevity·Christopher A SinklerMaik Hüttemann
Aug 27, 2017·Biochemical Society Transactions·Jian LiuShelagh Ferguson-Miller
Nov 24, 2004·The Journal of Biological Chemistry·Icksoo LeeMaik Hüttemann
Oct 8, 2020·World Journal of Biological Chemistry·Bernhard Kadenbach
Mar 7, 2021·Cells·Rabia RamzanSebastian Vogt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.