PMID: 537538Nov 1, 1979Paper

Regulation of the immune response by polyamines

Medical Hypotheses
D S Dwyer

Abstract

Regulation of the immune system is accomplished, in part, by numerous soluble factors and small molecules. One such class of regulatory substances may be the polyamines which are present in a variety of tissues. Stimulation of the immune response often occurs by crosslinking of lymphocyte surface proteins, followed by the production of some transmembrane signal. The activation pathway may be interrupted if certain necessary steps are blocked. It is proposed that polyamines exert regulatory influences by modulating crosslink formation; a step catalyzed by the enzyme transglutaminase. A model is outlined which describes the events initiating lymphocyte activation and the role of polyamines in this process. Certain drugs which might mimic the actions of polyamines are also discussed. During evolution of the control of growth processes in cells, relatively simple molecules (the polyamines) may have assumed a pivotal role in initiating and terminating the proliferative response. This idea has been applied to regulation of the immune system.

References

Jan 1, 1979·Biochemical Pharmacology·G G Shaw
May 10, 1979·Nature·K S Koch, H L Leffert
Jan 1, 1977·Advances in Protein Chemistry·J E Folk, J S Finlayson
Feb 24, 1979·Lancet·G H RabbaniI Lönnroth
Feb 27, 1975·Nature·D P Stites, R P Erickson
Sep 2, 1975·Biochemical and Biophysical Research Communications·Y MizoguchiS Morisawa
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·U Bachrach
Jan 1, 1978·Journal of Supramolecular Structure·M Vaughan, J Moss
Mar 15, 1979·Experimental Cell Research·L Hammarström, C I Smith
Jul 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·A Dutton, S J Singer
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J S PoberJ L Strominger
Jan 1, 1979·Biochemical Pharmacology·D V Maudsley
Feb 15, 1979·The Biochemical Journal·M A Melvin, H M Keir
Jul 20, 1978·Nature·S S Cohen
Jan 1, 1979·Journal of Neurochemistry·J N Hawthorne, M R Pickard
Jan 1, 1976·Annual Review of Biochemistry·C W Tabor, H Tabor
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R H FillingameD R Morris
Jan 15, 1975·Journal of Molecular Biology·D KaiserT Masuda
Jan 20, 1972·The New England Journal of Medicine·G Weissmann
Dec 8, 1972·Annals of the New York Academy of Sciences·S I Chung
Oct 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·S S CohenE Streibel
Feb 1, 1970·Biological Reviews of the Cambridge Philosophical Society·L Stevens
Sep 17, 1969·Biochimica Et Biophysica Acta·N Fausto
Feb 1, 1963·Journal of Bacteriology·N GROSSOWICZ, M ARIEL

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Citations

Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Sep 29, 1999·International Journal of Immunopharmacology·H VliagoftisT C Theoharides
May 1, 1983·Medical Hypotheses·F E Barr
Jan 1, 1982·Annals of the New York Academy of Sciences·L M Corwin, R K Gordon

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