Regulation of the immunoglobulin gene transcription

Biochimie
G Lefranc, M P Lefranc

Abstract

The transcription of the immunoglobulin heavy (IGH), kappa (IGK) and lambda (IGL) chain genes is coordinate and B lymphocyte specific. This expression of the immunoglobulin genes is under the control of regulatory elements: the promoters located 5' of each variable (V) gene and the enhancers located between the joining and constant genes in the IGH and IGK locus and downstream on the C kappa gene. These sequences represent sites for the binding of transcription factors. A 90-100 kDa ubiquitous proteins (NF-A1) as well as two specific B cell proteins (NF-A2, OTF-2B) bind to the octamer site of the V promoter and IGH enhancer. The NF-kB protein binds to the kB site in the intron kappa enhancer, but also to kB-like sites found in the promoter regions of other genes. This paper reviews the recent data on these factors and other transcription factors which bind to the promoters and enhancers of the immunoglobulin genes and control their expression.

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L OsbornG J Nabel
Jul 24, 1986·Nature·J V GarciaC Queen
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S Eaton, K Calame
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W PierceD Baltimore
Oct 28, 1988·Science·P A Baeuerle, D Baltimore
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A S Baldwin, P A Sharp
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T G ParslowD K Granner
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masao SakuraiChihiro Hama
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yao-Tseng ChenLloyd J Old

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Citations

Sep 1, 1991·International Journal of Cell Cloning·J H Kehrl
Jul 19, 2005·Immunogenetics·Huitong ZhouQian Fang
Sep 11, 2002·Molecular Immunology·Peter EllmarkMats Ohlin
Dec 29, 2009·Médecine sciences : M/S·Marie-Paule Lefranc
Jul 25, 2000·Toxicology and Applied Pharmacology·K C CrowthersM A Lynes
Jun 30, 2012·Proceedings of the National Academy of Sciences of the United States of America·Anthony P WestPamela J Bjorkman
Dec 23, 1998·Environmental Health Perspectives·B J BeatyA Rayms-Keller
Sep 4, 2020·Biomedicines·Marie-Paule Lefranc, Gérard Lefranc
Dec 3, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mahesh MohanXavier Alvarez
Jun 28, 2021·Genes and Immunity·Ivana MikocziovaLudvig M Sollid

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