PMID: 6968022Jan 1, 1980Paper

Regulation of the in vitro secondary cell-mediated cytotoxic response against syngeneic FBL-3 leukemia by macrophages

Microbiology and Immunology
T IgarashiY Yamamura

Abstract

Depletion of macrophages from immune spleen cells by treatment with carbonyl iron and magnet or by in vivo treatment with carrageenan enhanced the in vitro secondary cell-mediated cytotoxic response against a syngeneic Friend virus-induced leukemia, FBL-3 cells of C57BL/6 mice. However, further depletion of macrophages by passing the carbonyl iron-treated immune spleen cells through a nylon wool column abrogated the cytotoxic response. The addition of splenic macrophage-enriched preparations from either FBL-3-immune or normal mice suppressed the cytotoxic response of immune spleen cells treated with carbonyl iron and magnet. This suppressive effect of splenic macrophages presented a marked contrast with the enhancing effect of normal peritoneal macrophages on the same cell-mediated cytotoxic response, indicating regulation of the generation of killer T cells against a syngeneic tumor by functionally distinct macrophages. The suppressed cell-mediated cytotoxic response against FBL-3 cells by immune spleen cells was augmented by the addition of indomethacin to the culture medium, and this augmentation with indomethacin was greatly decreased by depletion of phagocytic cells from the immune spleen by treatment with carbonyl iron an...Continue Reading

References

Jan 1, 1977·Immunological Reviews·W F Davidson
Jan 1, 1978·Immunological Reviews·A C Allison
Aug 1, 1977·The Journal of Experimental Medicine·J W Dyminski, R T Smith
Jan 1, 1978·Immunological Reviews·E R Unanue
Jan 12, 1972·Nature: New Biology·J B HibbsJ S Remington
Nov 25, 1974·Prostaglandins·J Morley
Jun 23, 1971·Nature: New Biology·S H FerreiraJ R Vane

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