PMID: 42610Oct 1, 1979

Regulation of the induction of alkaline phosphatase in choriocarcinoma cells by sodium butyrate

In Vitro
J Y Chou


Alkaline phosphatase is induced in human choriocarcinoma cells by short-chain fatty acids, especially sodium butyrate. This fatty acid increases the phosphatase activity immediately and in a nearly linear fashion. Only phosphatase with an alkaline pH optimum is induced. Both the induced alkaline phosphatase and the basal enzyme are precipitated by antiserum against term-placental alkaline phosphatase, but the choriocarcinoma phosphatase is less stable to heating than is the term-placental enzyme. The induction of alkaline phosphatase activity requires cellular synthesis of protein, RNA and DNA. The regulation of induction probably occurs at the transcriptional level.


Apr 5, 1983·Biochimica Et Biophysica Acta·F Herz, M Halwer
Jan 1, 1995·Critical Reviews in Clinical Laboratory Sciences·J L Millán, W H Fishman
Mar 16, 1983·Biochemical and Biophysical Research Communications·F Ito, J Y Chou


Feb 1, 1976·In Vitro·K N Prasad, P K Sinha
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J Y Chou
Jan 1, 1978·The Journal of Clinical Endocrinology and Metabolism·R O HussaK W Scheuermann
May 1, 1978·Cell·L Sealy, R Chalkley
Feb 24, 1977·Nature·J M LieblichR P Cox
Apr 8, 1976·Nature·J M LieblichJ C Robinson
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·E GinsburgE Freese
Jul 10, 1974·Biochemical and Biophysical Research Communications·P H FishmanE Freese
May 1, 1971·The Journal of Clinical Endocrinology and Metabolism·P O Kohler, W E Bridson

Related Concepts

Fatty Acids, Volatile
Phosphoric Monoester Hydrolases
Transcription, Genetic
Uterine Cancer
Immune Sera
Alkaline Phosphatase Measurement
Alkaline Phosphatase
Alkaline Phosphatase Activity
Phosphoric Monoester Hydrolase Activity

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