PMID: 7537157Feb 1, 1995Paper

Regulation of the interferon-induced PKR: can viruses cope?

Trends in Microbiology
M G Katze

Abstract

Viruses that fail to block the lethal effects of the double-stranded-RNA-activated protein kinase (PKR) may be doomed; why do so many viruses go to so much trouble to downregulate this interferon-induced protein kinase? PKR may regulate cell growth and proliferation in uninfected cells, suggesting that it also participates in the antiproliferative arm of the interferon response.

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S GunneryM B Mathews
Dec 1, 1992·Genes & Development·S R Green, M B Mathews
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D St JohnstonM Jantsch
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T G LeeM G Katze
Nov 1, 1991·Journal of Virology·M B Mathews, T Shenk
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·F Imani, B L Jacobs
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·G N BarberM G Katze
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·H ParkS Venkatesan
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E F MeursA G Hovanessian
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·A KumarB R Williams

❮ Previous
Next ❯

Citations

May 8, 2003·Journal of Biosciences·G Waris, A Siddiqui
May 30, 2006·Virus Genes·Yehuda Stram, Larisa Kuzntzova
Sep 1, 1996·Comparative Immunology, Microbiology and Infectious Diseases·A Alcamí, G L Smith
Mar 31, 2005·Biochemical and Biophysical Research Communications·Annika OlssonGun Frisk
Apr 8, 2004·Virus Research·C Fabian Flores-JassoLuis Vaca
May 9, 2000·Mechanisms of Ageing and Development·W LadigesM Gale
Oct 11, 2003·Pharmacology & Therapeutics·Dhananjaya V Kalvakolanu
Aug 1, 1996·Current Opinion in Immunology·G L Smith
Jun 1, 1995·Trends in Biochemical Sciences·C G Proud
Jun 8, 2000·Immunity·M K Slifka, J L Whitton
Jan 4, 2001·Microbes and Infection·D R TaylorM M Lai
Jul 1, 1997·The International Journal of Biochemistry & Cell Biology·M J Clemens
Sep 18, 2003·Trends in Molecular Medicine·Judy LiebermanPremlata Shankar
Dec 1, 1995·Epidemiology and Infection·C A Mims
Feb 3, 2000·Nature Cell Biology·J M Bosher, M Labouesse
Dec 10, 1998·Nature Medicine·J H SimonM H Malim
Dec 22, 1999·Journal of Viral Hepatitis·J M Pawlotsky, G Germanidis
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alla Y KarpovaPeter M Howley
Mar 2, 1999·The Journal of Experimental Medicine·M CellaA Lanzavecchia
Oct 23, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M J Clemens, A Elia
Oct 22, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S L Tan, M G Katze
Dec 22, 2007·Nucleic Acids Research·Megan MittelstadtRekha C Patel
Mar 15, 1996·European Journal of Biochemistry·V M Pain
Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Oct 9, 2002·Journal of Virology·Ana Maria Rivas-EstillaAntonis E Koromilas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.