Regulation of the nitric oxide system in human adipose tissue.

Journal of Lipid Research
Stefan EngeliArya M Sharma

Abstract

Nitric oxide (NO) is involved in adipose tissue biology by influencing adipogenesis, insulin-stimulated glucose uptake, and lipolysis. The enzymes responsible for NO formation in adipose cells are endothelial NO synthase (eNOS) and inducible NO synthase (iNOS), whereas neuronal NO synthase (bNOS) is not expressed in adipocytes. We characterized the expression pattern and the influence of adipogenesis, obesity, and weight loss on genes belonging to the NO system in human subcutaneous adipose cells by combining in vivo and in vitro studies. Expression of most of the genes known to belong to the NO system (eNOS, iNOS, subunits of the soluble guanylate cyclase, and both genes encoding cGMP-dependent protein kinases) in human adipose tissue and isolated human adipocytes was detected. In vitro adipogenic differentiation increased the expression level of iNOS significantly, whereas eNOS expression levels were not influenced. The genes encoding eNOS, iNOS, and cGMP-dependent protein kinase 1 were expressed at higher levels in obese women. Expression of these genes, however, was not influenced by 5% weight loss. Insulin and angiotensin II (Ang II) increased NO production by human preadipocytes in vitro. Increased eNOS and iNOS expressio...Continue Reading

References

May 24, 1996·Biochemical and Biophysical Research Communications·C RibiereY Giudicelli
Apr 12, 1996·Molecular and Cellular Biochemistry·A B Vaandrager, H R de Jonge
Feb 7, 1998·Hypertension·B S HenningtonJ F Reckelhoff
Jun 5, 1998·The Journal of Biological Chemistry·N GaudiotC Ribière
Apr 8, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P Arner
May 14, 1999·British Journal of Pharmacology·K AnderssonP Arner
Aug 23, 2000·The Journal of Clinical Investigation·B B Kahn, J S Flier
Mar 15, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G PilonA Marette
Jul 6, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M RydénK Andersson
Oct 19, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K GorzelniakA M Sharma
Nov 10, 2001·The Journal of Clinical Endocrinology and Metabolism·K J MatherA D Baron
Jan 12, 2002·Obesity Research·Jürgen JankeArya M Sharma
Feb 16, 2002·Biochemical and Biophysical Research Communications·Catherine RibièreYves Giudicelli
Nov 28, 2002·Journal of Lipid Research·Hongyun YanDavid C W Lau
Jan 4, 2003·Hypertension·Michael BoschmannSusanne Klaus
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Stefan EngeliArya M Sharma
May 3, 2003·The Journal of Clinical Investigation·David VicentC Ronald Kahn
May 15, 2003·Endocrinology·Christopher J LyonWilla A Hsueh

❮ Previous
Next ❯

Citations

Jan 13, 2010·The Journal of Biological Chemistry·Ming-Fo Hsu, Tzu-Ching Meng
Dec 20, 2007·Current Opinion in Nephrology and Hypertension·Marcelo Alves-da-Silva MoriJoão Bosco Pesquero
Jan 10, 2009·Genome Génome / Conseil National De Recherches Canada·Karla R Kaun, Marla B Sokolowski
Mar 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Koji FujitaAtsushi Nakajima
Feb 25, 2014·Pharmacology & Therapeutics·Janette M Bulloch, Craig J Daly
May 30, 2014·Nutrition Research Reviews·Gema FrühbeckAmaia Rodríguez
Aug 22, 2014·Oxidative Medicine and Cellular Longevity·Soazig Le LayRamaroson Andriantsitohaina
Sep 23, 2008·The Journal of Experimental Biology·Karla R KaunMarla B Sokolowski
Nov 27, 2009·Cellular and Molecular Life Sciences : CMLS·Jongsung LeeDeokhoon Park
Oct 31, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hitoshi MinakuchiHiroshi Itoh
Jul 12, 2011·Trends in Endocrinology and Metabolism : TEM·Andrea ArmaniMassimiliano Caprio
Mar 14, 2009·Differentiation; Research in Biological Diversity·Caroline GummersbachNorbert Pallua
Jan 13, 2009·Free Radical Biology & Medicine·Thomas KoeckKulwant S Aulak
Mar 27, 2007·Biochemical and Biophysical Research Communications·Odile Poulain-Godefroy, Philippe Froguel
Oct 21, 2015·Communicative & Integrative Biology·Katia AquilanoCiriolo Maria Rosa
Jan 24, 2009·Obesity·Patricia Perez-MatuteFredrik Karpe
Nov 30, 2005·Immunological Reviews·Majd ZayzafoonJay M McDonald
Feb 1, 2012·Journal of the Science of Food and Agriculture·Hyuck Choi, Kyuho Myung
Aug 14, 2012·Journal of Tissue Engineering and Regenerative Medicine·Karsten HemmrichNorbert Pallua
Oct 13, 2007·Biochemical and Biophysical Research Communications·Maiko NozakiIichiro Shimomura
Mar 10, 2006·The Journal of Nutritional Biochemistry·Wenjuan Shi JobgenGuoyao Wu
Sep 13, 2005·Metabolism: Clinical and Experimental·Vaughna B GalvinRobert C Hickner
Jun 29, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Angelo Avogaro, Saula Vigili de Kreutzenberg
Mar 29, 2014·Drug Metabolism and Pharmacokinetics·Kazuki SawamotoKen-ichi Miyamoto
Aug 27, 2015·Gene Regulation and Systems Biology·Bai XueRichard R Almon
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Sofia B AhmedNorman K Hollenberg
Apr 26, 2007·The Journal of Clinical Endocrinology and Metabolism·Stefan EngeliJens Jordan
Sep 30, 2010·American Journal of Physiology. Endocrinology and Metabolism·Phillip J WhiteAndré Marette

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.