PMID: 9416923Jan 7, 1998Paper

Regulation of the polysialylated form of the neural cell adhesion molecule in the developing striatum: effects of cortical lesions

The Journal of Comparative Neurology
A K ButlerM F Chesselet

Abstract

Early in development, the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is expressed by growth cones, neuronal processes, and neuronal cell bodies. In rat striatum, PSA-NCAM expression becomes progressively restricted to pre- and postsynaptic membranes and is undetectable by postnatal day 25 (P25), i.e., after corticostriatal synaptogenesis. This study examined the effects of cortical lesions performed on P14, when the corticostriatal projection is already primarily unilateral and cortical inputs have not yet formed asymmetric synapses on striatal neurons. Rats were killed on P25, and PSA-NCAM expression was examined by immunoblotting and immunohistochemistry with light and electron microscopy. In contrast to the case in controls, PSA-NCAM expression was maintained in the striatum of lesioned pups. Ultrastructural studies showed that PSA-NCAM was present 1) in growth cone-like structures and neuronal processes and 2) in striatal neurons. Together with the presence of growth cones, the observation that the number of asymmetric synapses was unchanged in the denervated striatum suggests that axonal sprouting occurred in response to the lesion. This was confirmed by axonal labeling in the denervated striatum a...Continue Reading

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Citations

Mar 21, 2001·Behavioral Neuroscience·M J HigleyB J Strupp
Oct 13, 2006·Progress in Neurobiology·Luca Bonfanti
Dec 3, 2005·Experimental Neurology·Veronique Riban, Marie-Françoise Chesselet
Aug 18, 2000·The European Journal of Neuroscience·P MeyrandM P Nusbaum
Apr 7, 2005·Reviews in the Neurosciences·Màtè Daniel Döbrössy, Stephen B Dunnett

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