Regulation of the proteome by amino acids

Proteomics
Sandrine Bourgoin-VoillardC Moinard

Abstract

Besides their main contribution as substrates for protein synthesis, amino acids as signaling molecules could exert some regulatory functions on protein synthesis and/or proteolysis that have been emphasized in a number of recent studies. Several publications have highlighted supplemental roles of those amino acids in protein metabolism as well as in immunity, heat shock response, or apoptosis processes. In this way, via their regulatory properties, selected amino acids (such as leucine, glutamine, arginine, citrulline, or methionine) directly influence the proteome. In this review, we are proposing an overview of the regulation of the proteome by amino acids in mammals.

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Citations

Aug 31, 2016·Journal of Proteome Research·César Augusto-de-OliveiraAndré Zelanis
Aug 2, 2018·BioMed Research International·Letícia Dias Lima JedlickaNilson Antonio Assunção

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