Regulation of the rat p75 neurotrophin receptor promoter by GC element binding proteins

Biochemical and Biophysical Research Communications
H PoukkaJ J Palvimo

Abstract

Human and rat p75 neurotrophin receptor genes contain four conserved GC elements within their proximal promoter regions. These motifs are potentially recognized by many transcription factors. Here, we show that this proximal region of the rat gene is responsible for basal promoter function in both neuronal and non-neuronal cells. Coexpression of Wilms' tumor suppressor WT1 represses, whereas transcription factor Sp1 activates p75 promoter constructs in kidney cells. Furthermore, purified Sp1 protein binds with high affinity to p75 promoter elements as assayed by DNase I footprinting. These findings suggest an important role for the GC element binding proteins in the regulation of p75 promoter function.

Citations

Feb 13, 2002·Molecular and Cellular Biology·Shi-Hua LiXiao-Jiang Li
Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bernat Baeza-RajaKaterina Akassoglou
Oct 25, 2006·Journal of Neurochemistry·Naoki IshimaruMasaaki Tsuda
Oct 3, 2006·The Journal of Biological Chemistry·Jonathan CornettShi-Hua Li
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V A BotchkarevR Paus
Oct 6, 2017·Expert Review of Ophthalmology·Sally L Elshaer, Azza B El-Remessy
Mar 20, 2018·Chemico-biological Interactions·Safa Ben MimounaImed Messaoudi
May 20, 1998·Biochemical and Biophysical Research Communications·C Erck, K Seidl
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