Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids.

Proceedings of the National Academy of Sciences of the United States of America
Nadja MannowetzPolina V Lishko

Abstract

The calcium channel of sperm (CatSper) is essential for sperm hyperactivated motility and fertility. The steroid hormone progesterone activates CatSper of human sperm via binding to the serine hydrolase ABHD2. However, steroid specificity of ABHD2 has not been evaluated. Here, we explored whether steroid hormones to which human spermatozoa are exposed in the male and female genital tract influence CatSper activation via modulation of ABHD2. The results show that testosterone, estrogen, and hydrocortisone did not alter basal CatSper currents, whereas the neurosteroid pregnenolone sulfate exerted similar effects as progesterone, likely binding to the same site. However, physiological concentrations of testosterone and hydrocortisone inhibited CatSper activation by progesterone. Additionally, testosterone antagonized the effect of pregnenolone sulfate. We have also explored whether steroid-like molecules, such as the plant triterpenoids pristimerin and lupeol, affect sperm fertility. Interestingly, both compounds competed with progesterone and pregnenolone sulfate and significantly reduced CatSper activation by either steroid. Furthermore, pristimerin and lupeol considerably diminished hyperactivation of capacitated spermatozoa. T...Continue Reading

References

Apr 11, 1972·Biochemistry·A RuokonenR Vihko
Oct 1, 1980·Archives of Sexual Behavior·M F SchwartzW H Masters
Feb 1, 1996·Human Reproduction·C R HarlowM G Hull
Oct 1, 1996·Molecular Human Reproduction·A E CalogeroR D'Agata
Jun 29, 1999·British Journal of Pharmacology·T NakajimaH Hazama
Nov 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Manabu YoshidaMasaaki Morisawa
Jan 4, 2003·Nature Reviews. Molecular Cell Biology·Ralf Lösel, Martin Wehling
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anne E CarlsonDonner F Babcock
May 4, 2004·Biochemical and Biophysical Research Communications·Jason L ScraggChris Peers
Jul 15, 2005·Pharmacology·R S GuptaJ B S Kachhawa
Sep 15, 2005·Circulation·Chang-Xi BaiTetsushi Furukawa
Jun 21, 2006·Fertility and Sterility·María Eugenia TevesLaura Cecilia Giojalas
Oct 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jian QiuOline K Rønnekleiv
Jan 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Huayu QiDavid E Clapham
Mar 3, 2007·Nature Cell Biology·Stephen PublicoverChristopher Barratt
Jun 23, 2007·Human Reproduction Update·P G GroothuisC Punyadeera
Jul 16, 2008·Human Reproduction·R Oren-BenaroyaM Eisenbach
Jul 26, 2008·Human Reproduction Update·Susan S Suarez
Aug 28, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chunguang ZhangOline K Rønnekleiv
Oct 31, 2009·Chemistry & Biology·Alvin R KingDaniele Piomelli
Jan 13, 2011·Nature Communications·Jean-Ju ChungDavid E Clapham
Mar 18, 2011·Nature·Timo StrünkerU Benjamin Kaupp
Mar 18, 2011·Nature·Polina V LishkoYuriy Kirichok
Oct 25, 2011·Annual Review of Physiology·Polina V LishkoDavid E Clapham
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·James F SmithPolina V Lishko
Oct 3, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christian Harteneck
Oct 19, 2013·ELife·Nadja MannowetzPolina V Lishko
Jun 10, 2015·Nature Reviews. Urology·Vinod H Nargund
Jul 28, 2015·Endocrine Reviews·Jonathan W MuellerPaul A Foster
Apr 19, 2016·American Journal of Human Biology : the Official Journal of the Human Biology Council·Judyta NowakBoguslaw Pawlowski

❮ Previous
Next ❯

Citations

Feb 13, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Archana SrivastavFalgun W Bansode
Oct 13, 2017·Biology of Reproduction·Mari S Lehti, Anu Sironen
Jun 29, 2018·Journal of Cellular Physiology·Guillermina M LuqueMariano G Buffone
Jan 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Nadja MannowetzPolina V Lishko
Jan 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Christoph BrenkerTimo Strünker
Oct 31, 2019·Human Reproduction Update·Sean G BrownSarah J Martins da Silva
Jan 8, 2020·Journal of Assisted Reproduction and Genetics·Zuzana Trebichalská, Zuzana Holubcová
Dec 7, 2017·Oncotarget·Ruiying DiaoHsiao Chang Chan
Sep 19, 2019·Journal of Complementary & Integrative Medicine·Kayode Ezekiel Adewole, Alfred Francis Attah
Aug 16, 2017·Reproductive Biology and Endocrinology : RB&E·Xiang-Hong SunLi-Bo Sun
Sep 15, 2018·The Journal of Biological Chemistry·Gerardo OrtaAlberto Darszon
Feb 6, 2020·Frontiers in Cell and Developmental Biology·Julio C ChávezTakuya Nishigaki
Aug 11, 2020·Frontiers in Physiology·Anders RehfeldNiels Erik Skakkebæk
Aug 15, 2018·Frontiers in Cell and Developmental Biology·Lis C Puga MolinaMariano G Buffone
Mar 21, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Cintia Celina VaquerSilvia Alejandra Belmonte
Jan 6, 2021·Animals : an Open Access Journal From MDPI·Luis Alberto VieiraCarmen Matás
Nov 21, 2020·Nature Reviews. Urology·Huafeng WangJean-Ju Chung
Mar 17, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Vanessa Staldoni de OliveiraFátima Regina Mena Barreto Silva
Mar 24, 2021·The Journal of International Medical Research·Feng JiangXiaoxi Sun
Jul 28, 2020·Molecular and Cellular Endocrinology·Maya FinkelsteinHaim Breitbart
Jul 28, 2020·Molecular and Cellular Endocrinology·Rita Rahban, Serge Nef
Dec 20, 2020·Differentiation; Research in Biological Diversity·Paul S CookeEllis R Levin
Jul 3, 2021·Journal of Medicinal Chemistry·Giulia BononiCarlotta Granchi
Aug 13, 2021·Frontiers in Cell and Developmental Biology·Janice K JeschkeChristoph Brenker
Oct 12, 2021·Journal of Natural Products·Alana ShunnarahAngela I Calderón

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.