PMID: 6104810May 1, 1980Paper

Regulation of the synthesis of glutamine synthetase by the PII protein in Klebsiella aerogenes

Proceedings of the National Academy of Sciences of the United States of America
F FoorB Magasanik

Abstract

Certain mutations at the glaB locus result in the failure to fully derepress glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] and to convert it to the active nonadenylylated form in response to nitrogen limitation. In these mutants the PII regulatory protein is altered such that it cannot be converted by uridylyltransferase to the form stimulating deadenylylation of glutamine synthetase by adenylyltransferase. Additional mutations as well as insertions of transposon Tn5 at the glnB site result in the loss of PII. The loss of PII does not prevent adenylylation and deadenylylation of glutamine synthetase but reduces the rates of these reactions. Cells lacking PII have a high level of glutamine synthetase even when they are grown with an excess of ammonia and the enzyme is highly adenylylated. The results suggest that the PII protein plays a role, independent of its effect on adenylylation, in the regulation of the level of glutamine synthetase.

References

Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·F FoorB Magasanik
Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E GarciaS Kustu
Dec 1, 1978·Archives of Biochemistry and Biophysics·E G Engleman, S H Francis
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G Pahel, B Tyler
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S KustuN McFarland

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Citations

Jan 1, 1983·Molecular & General Genetics : MGG·A A Covarrubias, F Bastarrachea
Jan 1, 1982·Molecular & General Genetics : MGG·T MacNeilB Tyler
Feb 24, 2001·Trends in Microbiology·B Magasanik
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R A Ludwig
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D M RothsteinB Magasanik
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·V SundaresanF M Ausubel
Mar 10, 2001·Microbiology and Molecular Biology Reviews : MMBR·T ArcondéguyM Merrick
Oct 1, 1990·Molecular Microbiology·M Chiurazzi, M Iaccarino
Dec 1, 1989·Microbiological Reviews·J B StockA M Stock
Jul 1, 1992·Journal of Bacteriology·M R Atkinson, A J Ninfa
Jan 1, 1993·Journal of Bacteriology·S Maloy, V Stewart
Jul 1, 1997·Journal of Bacteriology·E M BenelliF O Pedrosa
Sep 1, 1982·Journal of Bacteriology·D B JanssenC van der Drift
Sep 1, 1982·Journal of Bacteriology·L J Reitzer, B Magasanik

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