PMID: 9662460Jul 14, 1998Paper

Regulation of the type II oncostatin M receptor expression in lung-derived epithelial cells

FEBS Letters
J CichyE Puré

Abstract

Oncostatin M (OSM) is a potent modulator of human lung-derived epithelial cell function. This cytokine binds two distinct receptor complexes: type I OSM receptor which is also a functional receptor for leukemia inhibitory factor (LIF), and type II OSM-specific receptor. The role of these two distinct receptors in mediating the response of individual cell types to OSM has not been delineated. In contrast to LIF, OSM induces synthesis of alpha1-antichymotrypsin and alpha1-antiproteinase inhibitor in lung-derived epithelial cells. The differential responsiveness to LIF and OSM suggested that the response of lung epithelial cells to OSM may be mediated by the OSM-specific receptor. Therefore, we characterized lung-derived epithelial cells for the expression of type II OSM receptor mRNAs, and the regulation of the mRNAs encoding the components of the OSM-specific receptor by cytokines and dexamethasone.

References

Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
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Citations

Mar 10, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·A GrenierS Chollet-Martin
Apr 29, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Randeep S JawaHeinz Baumann
Dec 1, 1999·Life Sciences·M J Gómez-Lechón

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